中国广西艾滋病病毒感染母亲所生婴儿的生长情况:2015-2021年为期18个月的纵向随访研究。

IF 2.8 3区 医学 Q2 INFECTIOUS DISEASES
HIV Medicine Pub Date : 2024-03-13 DOI:10.1111/hiv.13624
Jiangyang Zhao, Lingling Zhang, Linlin Li, Xiaohua Xie, Jianjun Li, Yuchen Wei, Yuanyuan Feng, Aidan Huang, Haifeng Huang, Qinghua Qin
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引用次数: 0

摘要

目标:预防艾滋病母婴传播已在全球取得成功。但是,人们对中国艾滋病病毒感染母亲所生婴儿的生长参数和艾滋病病毒感染婴儿的耐药性知之甚少。本研究旨在评估中国艾滋病病毒感染婴儿的生长参数和耐药性:我们对 2015 年 1 月至 2021 年 12 月期间广西壮族自治区感染 HIV 的母亲所生的 3283 名婴儿(3222 名未感染 HIV;61 名感染 HIV)进行了为期 18 个月的纵向随访研究。研究记录了所有参与者的体重和身长。此外,还对感染艾滋病毒的婴儿进行了基因亚型和耐药性分析:结果:与未感染艾滋病毒的婴儿相比,感染艾滋病毒的婴儿体重/身长 Z 值明显较低,18 个月大的婴儿除外。除 1 个月大的婴儿外,感染艾滋病毒的婴儿的身长/年龄 Z 值明显降低。感染艾滋病毒的婴儿在所有随访时间点的体重/年龄 Z 值都明显较低。在所有随访时间点,未感染艾滋病毒的男婴的体重/身长 Z 值都明显低于未感染艾滋病毒的女婴。除 1 个月大的婴儿外,未感染艾滋病毒的男婴在其余随访时间点的身长/年龄 Z 值和体重/年龄 Z 值均低于女婴。在总共 61 名感染艾滋病毒的婴儿中,37 个样本(60.66%)获得了亚型和耐药性数据。感染艾滋病毒的婴儿以 CRF01_AE 基因型为主,并显示出以非核苷类逆转录酶抑制剂耐药性为主的突变位点多样性:我们的研究显示了中国西南地区暴露于艾滋病病毒的婴儿的生长情况,并提供了关于艾滋病病毒感染者亚型分布和耐药性的详细信息。需要加强对艾滋病病毒感染婴儿的营养支持和耐药性监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Growth of infants delivered by mothers with HIV in Guangxi, China: An 18-month longitudinal follow-up study, 2015–2021

Objectives

The prevention of mother-to-child transmission of HIV has been a global success. But little is known about the growth parameters of infants delivered by mothers with HIV or the drug resistance of infants with HIV in China. The study aimed to assess growth parameters and drug resistance in Chinese infants exposed to HIV.

Methods

We conducted an 18-month longitudinal follow-up study of 3283 infants (3222 without HIV; 61 with HIV) born to mothers with HIV in the Guangxi Zhuang Autonomous Region between January 2015 and December 2021. The weight and length of all participants was recorded. In addition, genetic subtypes and drug resistance analysis were performed for infants with HIV.

Results

Compared with infants without HIV, those with HIV had significantly lower weight/length Z-scores, except at 18 months of age. The length/age Z-scores of infants with HIV was significantly reduced, except at 1 month of age. The weight/age Z-scores of infants with HIV were significantly lower at all follow-up time points. The weight/length Z-scores of male infants without HIV were significantly lower than for female infants without HIV at all follow-up time points. Male infants without HIV had lower length/age and weight/age Z-scores than female infants at the remaining follow-up points, except at 1 month of age. Of a total of 61 infants with HIV, subtype and drug-resistance data were obtained from 37 (60.66%) samples. Infants with HIV were dominated by the CRF01_AE genotype and showed a diversity of mutation sites dominated by non-nucleoside reverse transcriptase inhibitor resistance.

Conclusion

Our study demonstrates the growth of infants exposed to HIV in southwest China and provides detailed information on subtype distribution and drug resistance of those with HIV. Nutritional support and drug-resistance surveillance for infants exposed to HIV need to be strengthened.

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来源期刊
HIV Medicine
HIV Medicine 医学-传染病学
CiteScore
5.10
自引率
10.00%
发文量
167
审稿时长
6-12 weeks
期刊介绍: HIV Medicine aims to provide an alternative outlet for publication of international research papers in the field of HIV Medicine, embracing clinical, pharmocological, epidemiological, ethical, preclinical and in vitro studies. In addition, the journal will commission reviews and other feature articles. It will focus on evidence-based medicine as the mainstay of successful management of HIV and AIDS. The journal is specifically aimed at researchers and clinicians with responsibility for treating HIV seropositive patients.
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