颈动脉狭窄是经导管主动脉瓣植入术后脑卒中的预测因素。

IF 2.2 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Angiology Pub Date : 2025-10-01 Epub Date: 2024-03-13 DOI:10.1177/00033197241239687
Leonard Taube, Atsushi Sugiura, Arthur Hartmann, Christian Schaefer, Marwan Hamiko, Sebastian Zimmer, Georg Nickenig, Nadjib Schahab
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引用次数: 0

摘要

在经导管主动脉瓣植入术(TAVI)患者的长期随访中,中风仍然是一个临床风险。我们旨在研究现有颈动脉狭窄(CS)与 TAVI 术后中风风险之间的关系。研究对象是在 2008 年至 2020 年期间接受 TAVI 的连续患者,他们在基线和 30 天随访时接受了 CS 筛查。与血流动力学相关的CS定义为颈动脉口径相对于远段缩小>50%。本研究的主要终点是 TAVI 术后 30 天内的缺血性中风或短暂性脑缺血发作(TIA)。此外,还评估了与中风相关的死亡。在纳入的 1537 名患者中,220 名(14.3%)患者的 CS ≥50%。在 TAVI 术后 30 天内,41 名患者(2.7%)发生了缺血性中风或 TIA,7 人死于中风。从 TAVI 到中风/TIA 的中位时间为 3.0 天。CS≥50% 的患者在 TAVI 后发生卒中/TIA 的风险增加了 2.56 倍(95%CI:1.29-5.10,P = .006)。在调整性别、心房颤动和估计肾小球滤过率后,该关联在多变量模型中保持一致。需要进行研究以降低 CS≥50% 患者的中风风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Carotid Artery Stenosis as a Predictor for Stroke Following Transcatheter Aortic Valve Implantation.

Stroke remains a clinical risk in the long-term follow-up of patients after transcatheter aortic valve implantation (TAVI). We aimed to investigate the association between existing carotid artery stenosis (CS) and the risk of stroke after TAVI. The study participants were consecutive patients who underwent TAVI between 2008 and 2020 and were screened for CS at baseline and at the 30-day follow-up. Hemodynamically relevant CS was defined as a reduction of the carotid artery caliber by >50% in relation to the distal segment. The primary endpoint of this study was ischemic stroke or transient ischemic attack (TIA) within 30 days of TAVI. Stroke-related death was also assessed. Of the 1,537 patients included, 220 (14.3%) patients had CS ≥50%. Within 30 days following TAVI, 41 patients (2.7%) experienced an ischemic stroke or TIA, and seven had stroke-related death. The median time from TAVI to stroke/TIA was 3.0 days. Patients with CS ≥50% had a 2.56-fold increased risk of stroke/TIA after TAVI (95%CI: 1.29-5.10, P = .006). The association was consistent in the multivariable model after adjusting for sex, atrial fibrillation, and estimated glomerular filtration rate. Investigations are needed to mitigate the risk of stroke in patients with CS ≥50%.

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来源期刊
Angiology
Angiology 医学-外周血管病
CiteScore
5.50
自引率
14.30%
发文量
180
审稿时长
6-12 weeks
期刊介绍: A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days
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