饮食因素与皮肤黑色素瘤的关系:希腊病例对照研究及文献综述。

IF 2 4区 医学 Q3 ONCOLOGY
Oncology Research and Treatment Pub Date : 2024-01-01 Epub Date: 2024-03-12 DOI:10.1159/000538278
Andreas Katsimpris, Antonios G Antoniadis, Nick Dessypris, Konstantinos Karampinos, Helen J Gogas, Eleni T Petridou
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引用次数: 0

摘要

简介:营养可能会影响皮肤黑色素瘤(CM)的发病风险:据推测,营养可能会影响皮肤黑色素瘤(CM)的发病风险;因此,我们旨在评估希腊人群中食物种类和单项营养素摄入量与CM的相关性:在这项病例对照研究中,我们纳入了 151 名组织学确诊的皮肤黑色素瘤患者,他们都是在希腊雅典 "Laikon "大学医院肿瘤科接受治疗的新确诊患者;同时还纳入了 151 名年龄和性别相匹配的健康人,他们都居住在雅典大都会地区,是在常规健康检查参与者中招募的。所有参与者都填写了一份问卷,内容包括人体测量、社会人口学、生活方式和健康相关变量。他们还使用了一份经过验证的半定量食物频率问卷,以评估发病前 12 个月内 136 种食物的平均消耗量。采用多变量条件回归模型得出了九类食物和七种宏量营养素与中医的几率比(ORs)及 95% 置信区间(95% CI):在对阳光敏感性、重度抑郁症病史和酒精摄入量进行调整后,发现能量摄入量越高(OR:1.67,95% CI:1.22-2.30),饱和脂肪酸摄入量越高(OR:2.28,95% CI:1.00-5.28),与中风呈统计学意义上的正相关。此外,还观察到与牛奶和乳制品(OR:0.65,95% CI:0.48-0.88)、水果(OR:0.68,95% CI:0.51-0.90)、添加脂质(OR:0.65,95% CI:0.47-0.91)以及糖和糖浆(OR:0.70,95% CI:0.53-0.93)摄入量较高呈反向关系:除了内在的风险因素外,我们的研究结果还支持中医与多种食物组和营养素的关联;如果得到前瞻性研究的证实,这些发现将为这一致命癌症增添更多的知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations of Dietary Factors with Cutaneous Melanoma: A Case-Control Study in Greece with Literature Review.

Introduction: It has been postulated that nutrition may influence the risk for cutaneous melanoma (CM); therefore, we aimed to assess the associations of food groups and individual nutrient intakes with CM in a Greek population.

Methods: In this case-control study, 151 patients with histologically confirmed CM, newly diagnosed and treated in the Oncology Department of the "Laikon" University Hospital (Athens, Greece), and 151 age- and sex-matched healthy individuals residing in the Athens metropolitan area, recruited among participants for routine health examinations, were included. All participants completed a questionnaire comprising anthropometric measurements, sociodemographic, lifestyle, and health-related variables. A validated, semiquantitative food frequency questionnaire was used to assess average consumption of 136 food items during the 12 months preceding the onset of disease. Multivariate conditional regression models were used to derive odds ratios (ORs) with 95% confidence intervals (95% CI) regarding the association of nine food groups and seven macronutrients with CM.

Results: Statistically significant positive associations with CM were found with higher energy intake (OR: 1.67, 95% CI: 1.22-2.30) and intake of saturated fatty acids (OR: 2.28, 95% CI: 1.00-5.28), after adjusting for sun sensitivity, major depression history, and alcohol intake. Inverse associations with higher intake of milk and dairy products (OR: 0.65, 95% CI: 0.48-0.88), fruits (OR: 0.68, 95% CI: 0.51-0.90), added lipids (OR: 0.65, 95% CI: 0.47-0.91), and sugars and syrups (OR: 0.70, 95% CI: 0.53-0.93) were also observed.

Conclusions: Beyond intrinsic risk factors, our results support associations of CM with multiple food groups and nutrients; if confirmed by prospective studies, these findings can add further knowledge about this fatal cancer.

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来源期刊
CiteScore
3.20
自引率
0.00%
发文量
84
期刊介绍: With the first issue in 2014, the journal ''Onkologie'' has changed its title to ''Oncology Research and Treatment''. By this change, publisher and editor set the scene for the further development of this interdisciplinary journal. The English title makes it clear that the articles are published in English – a logical step for the journal, which is listed in all relevant international databases. For excellent manuscripts, a ''Fast Track'' was introduced: The review is carried out within 2 weeks; after acceptance the papers are published online within 14 days and immediately released as ''Editor’s Choice'' to provide the authors with maximum visibility of their results. Interesting case reports are published in the section ''Novel Insights from Clinical Practice'' which clearly highlights the scientific advances which the report presents.
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