脑脊液和血液中尸检药物浓度的比较分析。

IF 1.5 4区 医学 Q2 MEDICINE, LEGAL
Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-03-12 DOI:10.1007/s12024-024-00801-y
Paulina Wachholz, Rafał Celiński, Rafał Skowronek, Natalia Pawlas
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引用次数: 0

摘要

本研究旨在比较各种异种生物体在脑脊液(CSF)和血液中的浓度。我们对 175 例尸检病例进行了研究,这些病例的年龄、死因和药物摄入史各不相同,脑脊液和血液样本均可用于毒理学检测。研究的分析物包括阿片类、苯二氮卓类、抗抑郁药、抗精神病药以及大麻类、兴奋剂和新精神活性物质等非法药物,包括合成卡西酮和合成大麻素。我们发现,脑脊液中的浓度普遍低于血液中的浓度。许多分析物在脑脊液和血液中的药物浓度之间存在明显的相关性(p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative analysis of post-mortem drug concentrations in cerebrospinal fluid and blood.

This study aimed to compare the concentration of various xenobiotics in both cerebrospinal fluid (CSF) and blood. We examined 175 autopsy cases covering a wide range of ages, causes of death, and drug ingestion histories, with cerebrospinal fluid and blood samples available for toxicological testing. Analytes studied included opioids, benzodiazepines, antidepressants, antipsychotics, and illicit substances such as cannabinoids, stimulants and new psychoactive substances, including synthetic cathinones and synthetic cannabinoids. We found that concentrations in CSF were generally lower than in blood. A significant correlation was observed between drug concentrations in CSF and blood for many analytes (p < 0.05). However, the strength and direction of the correlation varied considerably depending on the physicochemical properties of the drugs, suggesting that a 'one size fits all' model may not be applicable. The results indicate that cerebrospinal fluid (CSF) can be used to detect a variety of xenobiotics, particularly amphetamines, synthetic cathinones and synthetic cannabinoids, in cases where conventional biological materials are not available. Additionally, using the results obtained in the future can lead to a better understanding of pharmacokinetic processes and the effect of post-mortem redistribution. Further research is needed to refine our understanding of these relationships.

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来源期刊
Forensic Science, Medicine and Pathology
Forensic Science, Medicine and Pathology MEDICINE, LEGAL-PATHOLOGY
CiteScore
3.90
自引率
5.60%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Forensic Science, Medicine and Pathology encompasses all aspects of modern day forensics, equally applying to children or adults, either living or the deceased. This includes forensic science, medicine, nursing, and pathology, as well as toxicology, human identification, mass disasters/mass war graves, profiling, imaging, policing, wound assessment, sexual assault, anthropology, archeology, forensic search, entomology, botany, biology, veterinary pathology, and DNA. Forensic Science, Medicine, and Pathology presents a balance of forensic research and reviews from around the world to reflect modern advances through peer-reviewed papers, short communications, meeting proceedings and case reports.
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