新生儿下丘脑的放射学特征与早期脂肪增长的关系

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2024-03-13 DOI:10.1111/ijpo.13114

Leticia E. Sewaybricker, Susan J. Melhorn, Sonja Entringer, Claudia Buss, Pathik D. Wadhwa, Ellen A. Schur, Jerod M. Rasmussen

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引用次数: 0

摘要

背景：基底中层下丘脑（MBH）是调节能量平衡的关键脑区。以往的神经影像学研究表明，成人和肥胖儿童中存在指示细胞炎症反应（胶质细胞增多症）的基于 T2 的信号特性，并可预测肥胖风险儿童的肥胖程度：本研究旨在将这一概念延伸到生命早期，研究在足月健康新生儿（最多 35 人）中，MBH 神经胶质增生的 MRI 证据是否与生命早期（新生儿到六个月）通过 DXA 测量的体脂百分比变化相关：在这项初步研究中，新生儿 MBH 的 T2 信号与六个月后体脂百分比的变化呈正相关：结论：这一发现支持了一种观点，即 MBH 的潜在过程可能在生命早期的生长过程中发挥作用，进而影响儿童肥胖风险。

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Associations of radiologic characteristics of the neonatal hypothalamus with early life adiposity gain

Background

The mediobasal hypothalamus (MBH) is a key brain area for regulation of energy balance. Previous neuroimaging studies suggest that T2-based signal properties indicative of cellular inflammatory response (gliosis) are present in adults and children with obesity, and predicts greater adiposity gain in children at risk of obesity.

Objectives/Methods

The current study aimed to extend this concept to the early life period by considering if, in full-term healthy neonates (up to n = 35), MRI evidence of MBH gliosis is associated with changes in early life (neonatal to six months) body fat percentage measured by DXA.

Results

In this initial study, neonatal T2 signal in the MBH was positively associated with six-month changes in body fat percentage.

Conclusion

This finding supports the notion that underlying processes in the MBH may play a role in early life growth and, by extension, childhood obesity risk.

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.