Gihan Hamdy Elsisi, Ang Yu Joe, Mollyza Mohd Zain, Habibah Mohd Yusoof, Cheng Lay Teh, Asmah Binti Mohd, Xiang Ting Khor, Liza Binti Mohd Isa
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One-way sensitivity analysis was also performed.</p><p><strong>Results: </strong>The number of target Malaysian patients with SLE in the COI model was 18,121. At diagnosis, the numbers of SLE patients with mild, moderate, and severe phenotypes were 2,582, 13,897, and 1,642, respectively. The total SLE cost in Malaysia over 5 years from both payer and society perspectives was estimated at MYR 678 million and 2 billion, respectively. The results showed a considerable cost burden due to productivity losses resulting from SLE-related morbidity and mortality. Over a 5-year time horizon, the costs per patient per year from the payer and society perspectives were MYR 7,484 ($4766) and 24,281($15,465), respectively.</p><p><strong>Conclusion: </strong>Our study demonstrated the substantial economic burden of SLE in Malaysia over a time horizon of 5 years. It affects adults of working age, in addition to the costs of SLE management and its consequences, such as flares, infection, and organ damage. Our COI model indicated that disease management costs among patients with higher disease severity were higher than those among patients with a mild phenotype. Hence, more attetion should be paid to limiting the progression of SLE and the occurrence of flares, with the need for further economic evaluation of novel treatments that could lead to better outcomes.</p>","PeriodicalId":16229,"journal":{"name":"Journal of Medical Economics","volume":"27 sup1","pages":"46-55"},"PeriodicalIF":2.9000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Economic burden of systemic lupus erythematosus in Malaysia.\",\"authors\":\"Gihan Hamdy Elsisi, Ang Yu Joe, Mollyza Mohd Zain, Habibah Mohd Yusoof, Cheng Lay Teh, Asmah Binti Mohd, Xiang Ting Khor, Liza Binti Mohd Isa\",\"doi\":\"10.1080/13696998.2024.2316537\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Our cost-of-illness (COI) model adopted the perspective of both payer and society over a time horizon of 5 years to measure the economic burden of systemic lupus erythematosus (SLE) in Malaysia.</p><p><strong>Methodology: </strong>Our COI model utilized a prevalence-based model to estimate the costs and economic consequences of SLE in Malaysia. 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引用次数: 0
摘要
导言:我们的疾病成本(COI)模型从支付方和社会的角度出发,以5年的时间跨度来衡量马来西亚系统性红斑狼疮(SLE)的经济负担:我们的 COI 模型采用了基于患病率的模型来估算马来西亚系统性红斑狼疮的成本和经济后果。临床参数来自已发表的文献,并通过德尔菲小组进行验证。直接和间接医疗成本包括疾病管理、短暂事件和间接成本。此外,还进行了单向敏感性分析:在 COI 模型中,目标马来西亚系统性红斑狼疮患者人数为 18 121 人。在确诊时,轻度、中度和重度表型的系统性红斑狼疮患者人数分别为 2582 人、13897 人和 1642 人。从支付方和社会角度估算,马来西亚系统性红斑狼疮患者在5年内的总成本分别为6.78亿马来西亚令吉和20亿马来西亚令吉。结果显示,由于系统性红斑狼疮相关的发病率和死亡率导致的生产力损失,造成了相当大的成本负担。在 5 年的时间跨度内,从支付方和社会角度来看,每位患者每年的成本分别为 7484 马币(4766 美元)和 24281 马币(15465 美元):我们的研究表明,系统性红斑狼疮给马来西亚带来了长达5年的巨大经济负担。除了系统性红斑狼疮的治疗费用及其后果(如复发、感染和器官损伤)外,它还影响着工作年龄段的成年人。我们的 COI 模型显示,疾病严重程度较高的患者的疾病管理成本要高于表型轻微的患者。因此,我们应该更加关注如何限制系统性红斑狼疮的进展和复发,并需要进一步对能带来更好疗效的新疗法进行经济评估。
Economic burden of systemic lupus erythematosus in Malaysia.
Introduction: Our cost-of-illness (COI) model adopted the perspective of both payer and society over a time horizon of 5 years to measure the economic burden of systemic lupus erythematosus (SLE) in Malaysia.
Methodology: Our COI model utilized a prevalence-based model to estimate the costs and economic consequences of SLE in Malaysia. The clinical parameters were obtained from published literature and validated using the Delphi panel. Direct and indirect medical costs were measured, including disease management, transient events, and indirect costs. One-way sensitivity analysis was also performed.
Results: The number of target Malaysian patients with SLE in the COI model was 18,121. At diagnosis, the numbers of SLE patients with mild, moderate, and severe phenotypes were 2,582, 13,897, and 1,642, respectively. The total SLE cost in Malaysia over 5 years from both payer and society perspectives was estimated at MYR 678 million and 2 billion, respectively. The results showed a considerable cost burden due to productivity losses resulting from SLE-related morbidity and mortality. Over a 5-year time horizon, the costs per patient per year from the payer and society perspectives were MYR 7,484 ($4766) and 24,281($15,465), respectively.
Conclusion: Our study demonstrated the substantial economic burden of SLE in Malaysia over a time horizon of 5 years. It affects adults of working age, in addition to the costs of SLE management and its consequences, such as flares, infection, and organ damage. Our COI model indicated that disease management costs among patients with higher disease severity were higher than those among patients with a mild phenotype. Hence, more attetion should be paid to limiting the progression of SLE and the occurrence of flares, with the need for further economic evaluation of novel treatments that could lead to better outcomes.
期刊介绍:
Journal of Medical Economics'' mission is to provide ethical, unbiased and rapid publication of quality content that is validated by rigorous peer review. The aim of Journal of Medical Economics is to serve the information needs of the pharmacoeconomics and healthcare research community, to help translate research advances into patient care and be a leader in transparency/disclosure by facilitating a collaborative and honest approach to publication.
Journal of Medical Economics publishes high-quality economic assessments of novel therapeutic and device interventions for an international audience