Chang Liu, Yuanyuan Zhang, Jing Wen, Ji Liu, Meirong Huo, Yan Shen, Hao Luo, Hui Zhang
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引用次数: 0
摘要
放射光热疗法是一种有效的癌症治疗方式。为了克服缺氧微环境中的放射抗性,提高放疗的敏感性,金属纳米颗粒和放射光热疗法被广泛应用于提高放疗疗效和减少放疗副作用的研究中。在此,我们开发了红血膜伪装铋纳米花(RBCM-BNF),具有出色的生理稳定性和生物降解性,可用于肺部肿瘤的治疗。体外数据证明,RBCM-BNF 与 X 射线照射和光热处理相结合,具有最强的癌细胞杀伤能力。同时,体内研究表明,RBCM-BNF 可抑制 HIF-1α 的表达,增加 caspase-3 的表达,从而缓解缺氧微环境,促进肿瘤细胞凋亡。因此,RBCM-BNF 具有良好的放射增敏作用,可能是一种很有前景的生物仿生纳米平台,可作为癌症的治疗靶点。
Red blood membrane camouflaging Bismuth nanoflowers designed for radio-photothermal therapy in lung cancer.
Radio-photothermal therapy is an effective modality for cancer treatment. To overcome the radio-resistance in the hypoxic microenvironment and improve the sensitivity of radiotherapy, metal nanoparticles, and radio-photothermal therapy are widely used in the research of improving the curative effect and reducing the side effects of radiotherapy. Here, we developed red blood membrane camouflaging bismuth nanoflowers (RBCM-BNF) with outstanding physiological stability and biodegradability for lung tumours. In vitro data proved that the RBCM-BNF had the greatest cancer cell-killing ability combined with X-ray irradiation and photo-thermal treatment. Meanwhile, in vivo studies revealed that RBCM-BNF can alleviate the hypoxic microenvironment and promote tumour cell apoptosis by inhibiting HIF-1α expression and increasing caspase-3 expression. Therefore, RBCM-BNF had a good radio-sensitising effect and might be a promising biomimetic nanoplatform as a therapeutic target for cancer.
期刊介绍:
Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs.
Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.