人类初乳中的促炎细胞因子水平(IL-1β、IL-6 和 TNF-α)与母体身体成分之间的关系

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Breastfeeding Medicine Pub Date : 2024-05-01 Epub Date: 2024-03-12 DOI:10.1089/bfm.2023.0263
María Murguía-Vázquez, Mariana Salgado-Bustamante, Victoria Lima-Rogel, José Andrés Flores-García, Mauricio Pierdant-Pérez
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引用次数: 0

摘要

背景:肥胖症是一种低度慢性炎症状态,以炎症生物标志物升高为特征。母乳(BM)富含营养元素、维生素、矿物质、免疫因子和生物活性成分。这些生物活性成分能够影响生物过程,其浓度可能因母体组成而异。研究目的/问题:本研究旨在探讨人类初乳中的促炎细胞因子(白细胞介素-1β [IL-1β]、白细胞介素-6 [IL-6]和肿瘤坏死因子-α [TNF-α])水平与母体成分之间的关系,并通过生物电阻抗矢量分析(BIVA)进行分析。研究方法在这项横断面研究中,共纳入了 117 名健康的产后参与者,按照生物电阻抗分析法的分类,每组(正常体重、超重和肥胖)包括 39 人。在产后 24 小时内采集初乳样本。结果IL-1β水平在各组间无明显差异,正常体重妇女为69.5 ± 103 pg/mL,超重妇女为79.7 ± 97.9 pg/mL,肥胖妇女为68.7 ± 108 pg/mL。超重组的 IL-6 水平(55 ± 72.4 pg/mL)明显高于正常体重组(48.1 ± 74.1 pg/mL)和肥胖组(28.9 ± 36.2 pg/mL)(p = 0.02)。同样,超重组的 TNF-α 浓度为 58.7 ± 74.9 pg/mL,高于正常体重组(38.6 ± 95.4 pg/mL)和肥胖组(52.6 ± 115 pg/mL)(P = 0.02)。结论本研究表明,超重妇女初乳中的IL-6和TNF-α浓度在统计学上更高,这表明母体的身体成分可能会影响BM的炎症特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association Between Pro-inflammatory Cytokine Levels (IL-1β, IL-6, and TNF-α) in Human Colostrum and Maternal Body Composition Components.

Background: Obesity is characterized as a low-grade chronic inflammatory state, marked by elevated inflammatory biomarkers. Breast milk (BM) is rich in nutritional elements, vitamins, minerals, immunological factors, and bioactive components. These bioactive components, capable of influencing biological processes, may vary in concentration based on maternal body composition. Research Aim/Question(s): This study aimed to explore the association between pro-inflammatory cytokine levels (interleukin-1 beta [IL-1β], interleukin-6 [IL-6], and tumor necrosis factor-alpha [TNF-α]) in human colostrum and maternal body composition, as analyzed through bioelectrical impedance vector analysis (BIVA). Method: In this cross-sectional study, 117 healthy postpartum participants were included, with each group (normal weight, overweight, and obese) comprising 39 individuals, as classified by BIVA. Colostrum samples were collected within the first 24 hours postpartum. Results: IL-1β levels did not significantly differ across the groups, with concentrations of 69.5 ± 103 pg/mL in normal-weight, 79.7 ± 97.9 pg/mL in overweight, and 68.7 ± 108 pg/mL in obese women. IL-6 levels were significantly higher in the overweight group (55 ± 72.4 pg/mL) than in the normal-weight (48.1 ± 74.1 pg/mL) and obese groups (28.9 ± 36.2 pg/mL) (p = 0.02). Similarly, TNF-α levels were higher in the overweight group, with concentrations of 58.7 ± 74.9 pg/mL, than in the normal-weight group, with concentrations of 38.6 ± 95.4 pg/mL, and 52.6 ± 115 pg/mL in obese women (p = 0.02). Conclusion: This study shows that IL-6 and TNF-α concentrations were statistically higher in the colostrum of overweight women, suggesting that maternal body composition may influence the inflammatory profile of BM.

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来源期刊
Breastfeeding Medicine
Breastfeeding Medicine OBSTETRICS & GYNECOLOGY-PEDIATRICS
CiteScore
4.20
自引率
11.10%
发文量
130
审稿时长
6-12 weeks
期刊介绍: Breastfeeding Medicine provides unparalleled peer-reviewed research, protocols, and clinical applications to ensure optimal care for mother and infant. The Journal answers the growing demand for evidence-based research and explores the immediate and long-term outcomes of breastfeeding, including its epidemiologic, physiologic, and psychological benefits. It is the exclusive source of the Academy of Breastfeeding Medicine protocols. Breastfeeding Medicine coverage includes: Breastfeeding recommendations and protocols Health consequences of artificial feeding Physiology of lactation and biochemistry of breast milk Optimal nutrition for the breastfeeding mother Breastfeeding indications and contraindications Managing breastfeeding discomfort, pain, and other complications Breastfeeding the premature or sick infant Breastfeeding in the chronically ill mother Management of the breastfeeding mother on medication Infectious disease transmission through breast milk and breastfeeding The collection and storage of human milk and human milk banking Measuring the impact of being a “baby-friendly” hospital Cultural competence and cultural sensitivity International public health issues including social and economic issues.
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