控制弓形虫和癌症适应性免疫的 TCR 信号

4区医学 Q2 Biochemistry, Genetics and Molecular Biology

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI:10.1007/978-981-99-9781-7_12

Masaaki Okamoto, Masahiro Yamamoto

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引用次数: 0

摘要

T 细胞在适应性免疫中发挥着至关重要的作用，它能识别并清除外来病原体和异常细胞（如癌细胞）。表达在 T 细胞表面的 T 细胞受体（TCR）能识别抗原递呈细胞（APC）上的主要组织相容性复合体（MHC）分子递呈的特异性抗原并与之结合。这一激活过程会导致 T 细胞的增殖和分化，使它们能够执行特定的免疫应答功能。本章概述了不同 T 细胞亚群共有的 TCR 信号通路，以及最近阐明的 CD8+ T 细胞特有的 TCR 信号通路及其在控制抗支原体和抗肿瘤免疫中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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TCR Signals Controlling Adaptive Immunity against Toxoplasma and Cancer.

T cells play a crucial role in adaptive immunity by recognizing and eliminating foreign pathogens and abnormal cells such as cancer cells. T cell receptor (TCR), which is expressed on the surface of T cells, recognizes and binds to specific antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). This activation process leads to the proliferation and differentiation of T cells, allowing them to carry out their specific immune response functions. This chapter outlines the TCR signaling pathways that are common to different T cell subsets, as well as the recently elucidated TCR signaling pathway specific to CD8⁺ T cells and its role in controlling anti-Toxoplasma and anti-tumor immunity.

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来源期刊

Advances in experimental medicine and biology 医学-医学：研究与实验

CiteScore

5.90

自引率

0.00%

发文量

465

审稿时长

2-4 weeks

期刊介绍： Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.