Qian Zhou , Lulin Qiao , An-An Zhang , Lu Li , Tuan-Jie Meng , Baomin Fan , Yuan-Yuan Gao , Lantao Liu
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Enantioselective synthesis of planar chiral ferrocenes via gold(I)-catalyzed hydroarylation of N-ferrocenyl propiolamides
Herein, we report an intramolecular 6-endo-dig cyclization of N-ferrocenyl propiolamides for the synthesis of planar chiral ferrocenes enabled by gold(I)-catalyzed hydroarylation. By using this protocol, a variety of planar chiral ferrocenopyridin-2(1H)-ones were obtained in good yields and excellent enantioselectivities (up to 96 % ee).
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