靶向 TRP 通道缓解疼痛：从临床到床边的现有证据综述

IF 4 3区医学 Q1 PHARMACOLOGY & PHARMACY

Current Opinion in Pharmacology Pub Date : 2024-03-11 DOI:10.1016/j.coph.2024.102447

Ari-Pekka Koivisto , Thomas Voets , Michael J. Iadarola , Arpad Szallasi

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引用次数: 0

摘要

数十年的研究支持瞬时受体电位（TRP）通道参与痛觉。尽管早期的 TRPV1 拮抗剂项目令人失望，但 TRP 家族仍然是治疗疼痛疾病的一个很有前景的靶点。高剂量辣椒素贴片已在临床上用于缓解神经性疼痛。目前，局部注射侧向 TRPV1 激动剂辣椒素和树脂铁氧体正在骨关节炎和骨癌疼痛患者中进行临床试验。TRPA1、TRPM3 和 TRPC5 通道也很受关注。本综述将讨论 TRP 通道在人类疼痛状况中的作用。

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Targeting TRP channels for pain relief: A review of current evidence from bench to bedside

Several decades of research support the involvement of transient receptor potential (TRP) channels in nociception. Despite the disappointments of early TRPV1 antagonist programs, the TRP family remains a promising therapeutic target in pain disorders. High-dose capsaicin patches are already in clinical use to relieve neuropathic pain. At present, localized injections of the side-directed TRPV1 agonist capsaicin and resiniferatoxin are undergoing clinical trials in patients with osteoarthritis and bone cancer pain. TRPA1, TRPM3, and TRPC5 channels are also of significant interest. This review discusses the role of TRP channels in human pain conditions.

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来源期刊

Current Opinion in Pharmacology 医学-药学

CiteScore

8.80

自引率

2.50%

发文量

131

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.