低温去蛋白牛骨异种移植在兔颅骨模型中的体内愈合。

IF 3.9 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Dina Abdelmoneim, Dawn Elizabeth Coates, Patrick Schmidlin, Sander Botter, Kai Chun Li, Gemma Claire Porter, Benedict Seo, Warwick John Duncan
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引用次数: 0

摘要

移植材料的理化性质会影响骨整合的质量、吸收率和新骨(NB)的形成。本研究评估了一种低温脱蛋白牛骨异种移植物(BBX)的理化性质和整合情况,这种牛骨异种移植物被称为优化的 MoaBone®(OMB)。这种新型 BBX 在化学漂白和伽玛辐照灭菌前后都进行了理化鉴定。使用兔子颅骨模型将 OMB 与 Bio-Oss® (BO) 和 MoaBone® (MB) 这两种商业 BBX 进行了比较。使用组织学和微型计算机断层扫描对残留移植物和 NB 进行量化。结果表明,化学处理和伽马射线照射对表面纹理的影响有限。化学处理后发现胶原蛋白含量明显减少,伽马射线照射后发现碳酸盐含量明显减少。没有发现炎症浸润、坏死或结缔组织包裹的迹象,与未经处理的缺损相比,所有移植部位的 NB 都有明显增加。不过,不同移植部位之间的差异在统计学上并不显著。我们的结论是,化学处理和终端消毒对最终移植物的特性有很大影响。在体内骨形成方面,OMB 移植物与 BO 具有同等效果,但可能会导致较低的移植物保留率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

In vivo healing of low temperature deproteinized bovine bone xenograft in a rabbit cranial model

In vivo healing of low temperature deproteinized bovine bone xenograft in a rabbit cranial model

The physicochemical properties of grafting materials affect the quality of the osteointegration, resorption rate, and the new bone (NB) formation. This study assessed the physicochemical properties and integration of a low temperature deproteinized bovine bone xenograft (BBX), referred to as optimized MoaBone® (OMB). This novel BBX was physiochemically characterized both pre and post chemical bleaching and sterilization by gamma irradiation. OMB was compared to two commercial BBX; Bio-Oss® (BO) and MoaBone® (MB) using a rabbit cranial model. Residual graft and NB were quantified using histology and micro-computed tomography. Results showed that chemical treatment and gamma irradiation had limited effect on the surface texture. A significant decrease in the collagen content was detected post chemical treatment and in the carbonate content post gamma irradiation. There was no evidence of inflammatory infiltrate, necrosis, or connective tissue encapsulation, and a significant increase of NB in all grafted sites as compared to untreated defects could be observed. However, there was no statistically significant difference between the grafted sites. We conclude that chemical treatment and terminal sterilization strongly impact the final graft's properties. OMB graft showed equivalence with BO for in vivo bone formation and potentially results in lower levels of graft retention.

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来源期刊
Journal of biomedical materials research. Part A
Journal of biomedical materials research. Part A 工程技术-材料科学:生物材料
CiteScore
10.40
自引率
2.00%
发文量
135
审稿时长
3.6 months
期刊介绍: The Journal of Biomedical Materials Research Part A is an international, interdisciplinary, English-language publication of original contributions concerning studies of the preparation, performance, and evaluation of biomaterials; the chemical, physical, toxicological, and mechanical behavior of materials in physiological environments; and the response of blood and tissues to biomaterials. The Journal publishes peer-reviewed articles on all relevant biomaterial topics including the science and technology of alloys,polymers, ceramics, and reprocessed animal and human tissues in surgery,dentistry, artificial organs, and other medical devices. The Journal also publishes articles in interdisciplinary areas such as tissue engineering and controlled release technology where biomaterials play a significant role in the performance of the medical device. The Journal of Biomedical Materials Research is the official journal of the Society for Biomaterials (USA), the Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Articles are welcomed from all scientists. Membership in the Society for Biomaterials is not a prerequisite for submission.
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