Long-COVID 时代的创伤性脑损伤。

IF 1.8 Q3 CLINICAL NEUROLOGY
Neurotrauma reports Pub Date : 2024-01-30 eCollection Date: 2024-01-01 DOI:10.1089/neur.2023.0067
Denes V Agoston
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引用次数: 0

摘要

已知生物背景或储备的主要决定因素,如年龄、生物性别、合并症(糖尿病、高血压、肥胖等)和药物(如抗凝药物)会影响创伤性脑损伤(TBI)后的结局。2019 年冠状病毒疾病(COVID-19;∼375,000 例,仍在统计中!)以及慢性形式的长COVID(也称为SARS-CoV-2感染急性后遗症(PASC))的数据无比丰富,出版物(∼30,000 例,仍在统计中)几乎涵盖了疾病、病理机制、生物标志物、疾病阶段、症状学等各个方面、这为更好地理解和认识疾病的整体性、器官系统之间的相互关联性以及生物背景在改变疾病轨迹和影响预后方面的重要性提供了一个独特的机会。为了更好地理解创伤性脑损伤引发的各种疾病,我们亟需这样一种整体方法。在此,我简要回顾了目前已知的长COVID/PASC、其潜在的疑似病理、创伤性脑损伤诱发的病理生物学变化(换言之,创伤性脑损伤内表型),讨论了长COVID/PASC与创伤性脑损伤诱发的病理生物学的交叉点,以及如何通过考虑影响患者生物背景的一些已知因素和纳入机理分子生物标志物来帮助改善创伤性脑损伤患者的临床管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Traumatic Brain Injury in the Long-COVID Era.

Major determinants of the biological background or reserve, such as age, biological sex, comorbidities (diabetes, hypertension, obesity, etc.), and medications (e.g., anticoagulants), are known to affect outcome after traumatic brain injury (TBI). With the unparalleled data richness of coronavirus disease 2019 (COVID-19; ∼375,000 and counting!) as well as the chronic form, long-COVID, also called post-acute sequelae SARS-CoV-2 infection (PASC), publications (∼30,000 and counting) covering virtually every aspect of the diseases, pathomechanisms, biomarkers, disease phases, symptomatology, etc., have provided a unique opportunity to better understand and appreciate the holistic nature of diseases, interconnectivity between organ systems, and importance of biological background in modifying disease trajectories and affecting outcomes. Such a holistic approach is badly needed to better understand TBI-induced conditions in their totality. Here, I briefly review what is known about long-COVID/PASC, its underlying-suspected-pathologies, the pathobiological changes induced by TBI, in other words, the TBI endophenotypes, discuss the intersection of long-COVID/PASC and TBI-induced pathobiologies, and how by considering some of the known factors affecting the person's biological background and the inclusion of mechanistic molecular biomarkers can help to improve the clinical management of TBI patients.

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来源期刊
CiteScore
2.40
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0.00%
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