Xu Wang Ph.D. , Hang Zhou B.M. , Chao-Qun Yan M.D. , Guang-Xia Shi M.D., Ph.D. , Ping Zhou M.M. , Jian-Wei Huo B.M. , Jing-Wen Yang M.D., Ph.D. , Ya-Nan Zhang M.D. , Lu Wang B.M. , Yan Cao M.M. , Cun-Zhi Liu M.D., Ph.D.
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引用次数: 0
摘要
客观综合证据表明，主观认知能力下降（SCD）可能是痴呆症的早期指标。海马区是认知障碍发展过程中最早受到影响的区域。然而，对于针灸是否以及如何改变 SCD 患者的海马结构和功能却知之甚少。结果在干预结束时，与假针灸相比，接受针灸治疗的参与者在多领域神经心理测试的综合 Z 评分方面有所改善，海马体积和功能连接也有所增加。结论：这些研究结果表明，针灸可改善 SCD 患者的认知功能，在区域层面上增加海马体积，在结缔层面上增强海马的结构和功能连接。
Cognitive and Hippocampal Changes in Older Adults With Subjective Cognitive Decline After Acupuncture Intervention
Objective
Converging evidence indicates that subjective cognitive decline (SCD) could be an early indicator of dementia. The hippocampus is the earliest affected region during the progression of cognitive impairment. However, little is known about whether and how acupuncture change the hippocampal structure and function of SCD individuals.
Methods
Here, we used multi-modal MRI to reveal the mechanism of acupuncture in treating SCD. Seventy-two older participants were randomized into acupuncture or sham acupuncture group and treated for 12 weeks.
Results
At the end of the intervention, compared to sham acupuncture, participants with acupuncture treatment showed improvement in composite Z score from multi-domain neuropsychological tests, as well as increased hippocampal volume and functional connectivity. Moreover, the greater white matter integrity of the fornix, which is the major output tract of the hippocampus, was shown in the acupuncture group.
Conclusion
These findings suggest that acupuncture may improve the cognitive function of SCD individuals, and increase hippocampal volume on the regional level and enhance the structural and functional connectivity of hippocampus on the connective level.
期刊介绍：
The American Journal of Geriatric Psychiatry is the leading source of information in the rapidly evolving field of geriatric psychiatry. This esteemed journal features peer-reviewed articles covering topics such as the diagnosis and classification of psychiatric disorders in older adults, epidemiological and biological correlates of mental health in the elderly, and psychopharmacology and other somatic treatments. Published twelve times a year, the journal serves as an authoritative resource for professionals in the field.
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