用于抗菌和伤口敷料的可注射热敏肉桂醛负载壳聚糖水凝胶的合成

IF 2.9 4区 医学 Q1 Medicine
Xun Che, Yu-Ling Wu, Qing-Ling He, Zhen Wu, Shi-Bo Wang, Han Zhang, M. Zubair Iqbal, Fei Liu, Jia-Ju Lu, Xiangdong Kong
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引用次数: 0

摘要

细菌感染情况下的伤口愈合是一个复杂的过程,也是一个长期的挑战,对人类健康有严重影响。为解决这一问题,作为一种潜在的解决方案,可注射的热敏水凝胶伤口敷料受到了广泛关注。在这项研究中,我们以壳聚糖(CS)和β-甘油磷酸酯(β-GP)为基础,用一系列肉桂醛(CA)进行改性,开发了一种用于伤口愈合的可注射抗菌热敏水凝胶。CS/β-GP/CA 凝胶在体温下会发生相变,具有良好的生物相容性。与未改性的 CS/β-GP 水凝胶相比,CA 的加入可促进内皮细胞的生长和水凝胶系统的抗菌性,从而加快伤口愈合和组织再生。我们的研究结果表明,CS/β-GP/CA 热敏水凝胶有望成为伤口治疗中可注射伤口敷料的候选材料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis of Injectable Thermosensitive Cinnamaldehyde-Loaded Chitosan Hydrogel for Antibacterial and Wound Dressing Application
The wound healing in the presence of bacterial infections is a complex process and prolonged challenge with severe implications for human health. To address this issue, injectable thermo-sensitive hydrogels as wound dressings have garnered considerable attention as a potential solution. In this study, we have developed an injectable and antibacterial thermosensitive hydrogel for wound healing, based on chitosan (CS) and β-glycerophosphate (β-GP) and modified with a range of cinnamaldehyde (CA). The CS/β-GP/CA gels demonstrate a phase transition at body temperatures, and exhibit good biocompatibility. Compared with the unmodified CS/β-GP hydrogels, incorporating CA can promote endothelial cell growth and the antibacterial property of the hydrogel system, which may lead to faster wound healing and tissue regeneration. Our findings suggest that the CS/β-GP/CA thermosensitive hydrogel emerges as a promising candidate for an injectable wound dressing in wound treatments.
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来源期刊
CiteScore
4.30
自引率
17.20%
发文量
145
审稿时长
2.3 months
期刊介绍: Information not localized
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