Yang Zhang, Jianfei Wang, Hao Dai, Ning Li, Fen Hu, Bolin Zhang, Yiming Yang, Haifeng Cai, Jinyin Yan
{"title":"纤维素纳米纸携带的顺式铂和 CXCR4 siRNA 限制了乳腺癌细胞的生物效应","authors":"Yang Zhang, Jianfei Wang, Hao Dai, Ning Li, Fen Hu, Bolin Zhang, Yiming Yang, Haifeng Cai, Jinyin Yan","doi":"10.1166/jbn.2024.3802","DOIUrl":null,"url":null,"abstract":"Cellulose nanopaper (CNP) is a kind of flat foldable film material composed of cellulose nanofibers. Cellulose nanopaper is based on nanocellulose (NC) as the basic unit, with excellent mechanical properties, thermal properties, optical properties and other characteristics, is a high-performance\n new material. This study discusses the mechanism of cis-platinum and CXCR4 siRNA carried with CNP in restraining the biological effect of breast carcinoma cells. CXCR4 siRNA carried with CNP was established and identified. The MCF-7 cells were divided into control set, si-CXCR4 set, cis-platinum\n set and united set randomly. The proliferative and apoptotic activity, CXCR4 presentation, presentation of EMT, and invasive ability were detected. mRNA and protein expression of CXCR4 was restrained by knockdown of CXCR4 notably. The proliferation was restrained and apoptosis was prompted.\n Expression of E-cadherin was increased and Zeb1 presentation was reduced. The invasive ability was restrained. The action was more notable in united set. Breast carcinoma cell proliferation was restrained and the apoptosis was prompted by cis-platinum and CXCR4 siRNA carried with CNP. The\n occurrence of EMT and invasion were therefore restrained. The sensibility of breast carcinoma on drugs was elevated.","PeriodicalId":15260,"journal":{"name":"Journal of biomedical nanotechnology","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cis-Platinum and CXCR4 siRNA Carried with Cellulose Nanopaper Restrain the Biological Effect of Breast Carcinoma Cells\",\"authors\":\"Yang Zhang, Jianfei Wang, Hao Dai, Ning Li, Fen Hu, Bolin Zhang, Yiming Yang, Haifeng Cai, Jinyin Yan\",\"doi\":\"10.1166/jbn.2024.3802\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cellulose nanopaper (CNP) is a kind of flat foldable film material composed of cellulose nanofibers. Cellulose nanopaper is based on nanocellulose (NC) as the basic unit, with excellent mechanical properties, thermal properties, optical properties and other characteristics, is a high-performance\\n new material. This study discusses the mechanism of cis-platinum and CXCR4 siRNA carried with CNP in restraining the biological effect of breast carcinoma cells. CXCR4 siRNA carried with CNP was established and identified. The MCF-7 cells were divided into control set, si-CXCR4 set, cis-platinum\\n set and united set randomly. The proliferative and apoptotic activity, CXCR4 presentation, presentation of EMT, and invasive ability were detected. mRNA and protein expression of CXCR4 was restrained by knockdown of CXCR4 notably. The proliferation was restrained and apoptosis was prompted.\\n Expression of E-cadherin was increased and Zeb1 presentation was reduced. The invasive ability was restrained. The action was more notable in united set. Breast carcinoma cell proliferation was restrained and the apoptosis was prompted by cis-platinum and CXCR4 siRNA carried with CNP. The\\n occurrence of EMT and invasion were therefore restrained. The sensibility of breast carcinoma on drugs was elevated.\",\"PeriodicalId\":15260,\"journal\":{\"name\":\"Journal of biomedical nanotechnology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of biomedical nanotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1166/jbn.2024.3802\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biomedical nanotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1166/jbn.2024.3802","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
Cis-Platinum and CXCR4 siRNA Carried with Cellulose Nanopaper Restrain the Biological Effect of Breast Carcinoma Cells
Cellulose nanopaper (CNP) is a kind of flat foldable film material composed of cellulose nanofibers. Cellulose nanopaper is based on nanocellulose (NC) as the basic unit, with excellent mechanical properties, thermal properties, optical properties and other characteristics, is a high-performance
new material. This study discusses the mechanism of cis-platinum and CXCR4 siRNA carried with CNP in restraining the biological effect of breast carcinoma cells. CXCR4 siRNA carried with CNP was established and identified. The MCF-7 cells were divided into control set, si-CXCR4 set, cis-platinum
set and united set randomly. The proliferative and apoptotic activity, CXCR4 presentation, presentation of EMT, and invasive ability were detected. mRNA and protein expression of CXCR4 was restrained by knockdown of CXCR4 notably. The proliferation was restrained and apoptosis was prompted.
Expression of E-cadherin was increased and Zeb1 presentation was reduced. The invasive ability was restrained. The action was more notable in united set. Breast carcinoma cell proliferation was restrained and the apoptosis was prompted by cis-platinum and CXCR4 siRNA carried with CNP. The
occurrence of EMT and invasion were therefore restrained. The sensibility of breast carcinoma on drugs was elevated.