Single-Carbon Atom Doping Reactions Using Atomic Carbon and Its Equivalents

Atomic carbon, a zerovalent atom with four non-bonded electrons, has potential utility in organic synthesis as platforms for the formation of four new covalent bonds at the carbon center. Single-carbon atom doping (SCAD) is the process of inserting an atomic carbon into a reactant molecule with no loss of atoms in the reactant. In this Concept, we overview SCAD reactions, which can be classified by physical or chemical methods.