氟特罗聚氧乙烯醚会对小鼠造成发育毒性

IF 3.5 Q3 ENGINEERING, ENVIRONMENTAL
Katherine L. Steeves, Jenna Hanrahan, Nikita E. Harvey, Karl J. Jobst and Lindsay S. Cahill
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引用次数: 0

摘要

多氟和全氟烷基物质是一类无处不在的化合物,被认为是持久性有机污染物。其中许多化合物不受管制,研究不足,但仍被广泛使用。氟代聚氧乙烯醚是其中一类化合物,最近在环境中被检测到后成为人们关注的化合物。为了确定这些持久性化合物对健康的影响,健康的妊娠 CD-1 小鼠在整个妊娠期分别接触了饮用水中 0 纳克/升(8 只)、5 纳克/升(8 只)或 100 纳克/升(7 只)的氟特罗姆聚氧乙烯醚。在妊娠 17.5 天(足月为 18.5 天)时,进行高频超声波检查,以研究胎盘和胎儿在接触后的血流动力学反应。母体接触氟特罗姆聚氧乙烯醚后,有证据表明胎盘功能不全,胎盘重量显著增加(p < 0.05),脐动脉血流减少(p < 0.01),脑循环血管扩张(p < 0.01),这与保护大脑供氧的脑疏通一致。这些结果表明,氟特罗聚氧乙烯醚会导致发育毒性,因此需要进一步开展工作,评估其对人类孕妇和其他易感人群的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Fluorotelomer ethoxylates cause developmental toxicity in mice

Fluorotelomer ethoxylates cause developmental toxicity in mice

Fluorotelomer ethoxylates cause developmental toxicity in mice

Poly- and perfluoroalkyl substances are a ubiquitous class of compounds which are considered persistent organic pollutants. Many of these compounds are unregulated and understudied but are still widely used. One group of these compounds are fluorotelomer ethoxylates, which recently emerged as compounds of interest following their detection in the environment. To determine the health impacts of these persistent compounds, healthy pregnant CD-1 mice were exposed to 0 ng L−1 (n = 8), 5 ng L−1 (n = 8), or 100 ng L−1 (n = 7) fluorotelomer ethoxylates in drinking water throughout gestation. At gestational day 17.5 (term is 18.5 days), high-frequency ultrasound was performed to investigate the placental and fetal hemodynamic responses following exposure. Maternal exposure to fluorotelomer ethoxylates showed evidence of placental insufficiency, with a significant increase in placental weights (p < 0.05), a decrease in the umbilical artery blood flow (p < 0.01) and vasodilation of the cerebral circulation (p < 0.01), consistent with brain sparing to preserve oxygen delivery to the brain. These results demonstrate that fluorotelomer ethoxylates cause developmental toxicity and motivate further work to evaluate the risk to human pregnancies and other vulnerable populations.

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