I. D. Strazhesko, A. P. Yesakova, A. A. Akopyan, O. N. Tkacheva
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引用次数: 0
摘要
摘要衰老过程是一种复杂的生物学现象，受遗传、环境和生活方式等多种因素的影响。最近的研究表明，表观遗传修饰在衰老过程中起着重要作用，因为它们能调控基因表达并最终影响细胞功能。表观遗传修饰包括 DNA 甲基化、组蛋白修饰和非编码 RNA 表达等。这篇综述的作者讨论了 DNA 甲基化在调控基因表达中的作用及其与癌症和神经变性等老年相关疾病的关系。文章还综述了组蛋白修饰的作用及其对染色质结构和基因表达的影响。此外，综述还提供了有关衰老分子标志物参与老年相关疾病的信息。了解表观遗传机制在衰老中的作用对于开发新的干预措施至关重要，这些措施有可能减缓甚至逆转衰老过程。
The process of aging is a complex biological phenomenon that is influenced by multiple factors, including genetics, environment, and lifestyle. Recent studies have shown that epigenetic modifications play an important role in the aging process, as they regulate gene expression and ultimately affect cellular function. Epigenetic modifications include DNA methylation, histone modification, and non-coding RNA expression, among others. The authors of the review discuss the role of DNA methylation in regulating gene expression and its relationship to age-related diseases such as cancer and neurodegeneration. Also, the role of histone modification and its impact on chromatin structure and gene expression is reviewed in the article. Additionally, review provides information on the involvement of molecular hallmarks of aging in age-related diseases. Understanding the role of epigenetic mechanisms in aging is crucial for developing new interventions that could potentially slow down or even reverse the aging process.
期刊介绍：
Advances in Gerontology focuses on biomedical aspects of aging. The journal also publishes original articles and reviews on progress in the following research areas: demography of aging; molecular and physiological mechanisms of aging, clinical gerontology and geriatrics, prevention of premature aging, medicosocial aspects of gerontology, and behavior and psychology of the elderly.
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