Tian-tian Meng , Ya-ping You , Min Li , Jian-bo Guo , Xin-bin Song , Jing-yi Ding , Xiao-long Xie , An-qi Li , Shang-jin Li , Xiang-jun Yin , Peng Wang , Zhe Wang , Bao-liang Wang , Qing-yong He
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Recently, several systematic reviews (SRs) and meta-analyses (MAs) of GBLPs for IS have been published.</p></div><div><h3>Objective</h3><p>This overview aims to assess the quality of related SRs and MAs.</p></div><div><h3>Search strategy</h3><p>PubMed, Embase, Cochrane Library, Web of Science, Chinese Biological Medicine, China National Knowledge Infrastructure, Wanfang, and Chinese Science and Technology Journals databases were searched from their inception to December 31, 2022.</p></div><div><h3>Inclusion criteria</h3><p>SRs and MAs of randomized controlled trials (RCTs) that explored the efficacy of GBLPs for patients with IS were included.</p></div><div><h3>Data extraction and analysis</h3><p>Two independent reviewers extracted data and assessed the methodological quality, risk of bias (ROB), reporting quality, and credibility of evidence of the included SRs and MAs using A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2), Risk of Bias in Systematic Reviews (ROBIS), the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), and the Grading of Recommendations Assessment, Development and Evaluation (GRADE), respectively. Additionally, descriptive analysis and data synthesis were conducted.</p></div><div><h3>Results</h3><p>Twenty-nine SRs/MAs involving 119 outcomes were included in this review. The overall methodological quality of all SRs/MAs was critically low based on AMSTAR 2, and 28 had a high ROB based on the ROBIS. According to the PRISMA statement, the reporting items of the included SRs/MAs are relatively complete. The results based on GRADE showed that of the 119 outcomes, 8 were rated as moderate quality, 24 as low quality, and 87 as very low quality. Based on the data synthesis, GBLPs used in conjunction with conventional treatment were superior to conventional treatment alone for decreasing neurological function scores.</p></div><div><h3>Conclusion</h3><p>GBLPs can be considered a beneficial supplemental therapy for IS. 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Chinese herbal medicine <em>Ginkgo biloba</em> L. preparations for ischemic stroke: An overview of systematic reviews and meta-analyses. <em>J Integr Med</em>. 2024;22(2): 163–179.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 2","pages":"Pages 163-179"},"PeriodicalIF":4.2000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Chinese herbal medicine Ginkgo biloba L. preparations for ischemic stroke: An overview of systematic reviews and meta-analyses\",\"authors\":\"Tian-tian Meng , Ya-ping You , Min Li , Jian-bo Guo , Xin-bin Song , Jing-yi Ding , Xiao-long Xie , An-qi Li , Shang-jin Li , Xiang-jun Yin , Peng Wang , Zhe Wang , Bao-liang Wang , Qing-yong He\",\"doi\":\"10.1016/j.joim.2024.03.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p><em>Ginkgo biloba</em> L. preparations (GBLPs) are a class of Chinese herbal medicine used in the adjuvant treatment of ischemic stroke (IS). 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引用次数: 0
摘要
国标中药制剂（GBLPs）是一类用于缺血性中风（IS）辅助治疗的中药。最近，发表了多篇关于GBLPs治疗缺血性中风的系统综述（SR）和荟萃分析（MA）。本综述旨在评估相关 SR 和 MA 的质量。本综述共纳入了29篇SR/MA，涉及119项结果。根据AMSTAR 2，所有SR/MA的总体方法学质量为极低，根据ROBIS，28项为高ROB。根据 PRISMA 声明，纳入的 SR/MA 的报告项目相对完整。基于 GRADE 的结果显示，在 119 项结果中，8 项被评为中等质量，24 项为低质量，87 项为极低质量。根据数据综合，在降低神经功能评分方面，GBLPs 与常规治疗联合使用优于单独使用常规治疗。GBLPs可被视为IS的有益补充疗法。然而，由于现有证据的质量较低，因此需要进行高质量的 RCT 和 SR/MA，以进一步评估 GBLPs 对治疗 IS 的益处。
Chinese herbal medicine Ginkgo biloba L. preparations for ischemic stroke: An overview of systematic reviews and meta-analyses
Background
Ginkgo biloba L. preparations (GBLPs) are a class of Chinese herbal medicine used in the adjuvant treatment of ischemic stroke (IS). Recently, several systematic reviews (SRs) and meta-analyses (MAs) of GBLPs for IS have been published.
Objective
This overview aims to assess the quality of related SRs and MAs.
Search strategy
PubMed, Embase, Cochrane Library, Web of Science, Chinese Biological Medicine, China National Knowledge Infrastructure, Wanfang, and Chinese Science and Technology Journals databases were searched from their inception to December 31, 2022.
Inclusion criteria
SRs and MAs of randomized controlled trials (RCTs) that explored the efficacy of GBLPs for patients with IS were included.
Data extraction and analysis
Two independent reviewers extracted data and assessed the methodological quality, risk of bias (ROB), reporting quality, and credibility of evidence of the included SRs and MAs using A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2), Risk of Bias in Systematic Reviews (ROBIS), the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), and the Grading of Recommendations Assessment, Development and Evaluation (GRADE), respectively. Additionally, descriptive analysis and data synthesis were conducted.
Results
Twenty-nine SRs/MAs involving 119 outcomes were included in this review. The overall methodological quality of all SRs/MAs was critically low based on AMSTAR 2, and 28 had a high ROB based on the ROBIS. According to the PRISMA statement, the reporting items of the included SRs/MAs are relatively complete. The results based on GRADE showed that of the 119 outcomes, 8 were rated as moderate quality, 24 as low quality, and 87 as very low quality. Based on the data synthesis, GBLPs used in conjunction with conventional treatment were superior to conventional treatment alone for decreasing neurological function scores.
Conclusion
GBLPs can be considered a beneficial supplemental therapy for IS. However, because of the low quality of the existing evidence, high-quality RCTs and SRs/MAs are warranted to further evaluate the benefits of GBLPs for treating IS.
Please cite this article as: Meng TT, You YP, Li M, Guo JB, Song XB, Ding JY, Xie XL, Li AQ, Li SJ, Yin XJ, Wang P, Wang Z, Wang BL, He QY. Chinese herbal medicine Ginkgo biloba L. preparations for ischemic stroke: An overview of systematic reviews and meta-analyses. J Integr Med. 2024;22(2): 163–179.
期刊介绍：
The predecessor of JIM is the Journal of Chinese Integrative Medicine (Zhong Xi Yi Jie He Xue Bao). With this new, English-language publication, we are committed to make JIM an international platform for publishing high-quality papers on complementary and alternative medicine (CAM) and an open forum in which the different professions and international scholarly communities can exchange views, share research and their clinical experience, discuss CAM education, and confer about issues and problems in our various disciplines and in CAM as a whole in order to promote integrative medicine.
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JIM is published bimonthly. Manuscripts submitted to JIM should be written in English. Article types include but are not limited to randomized controlled and pragmatic trials, translational and patient-centered effectiveness outcome studies, case series and reports, clinical trial protocols, preclinical and basic science studies, systematic reviews and meta-analyses, papers on methodology and CAM history or education, conference proceedings, editorials, commentaries, short communications, book reviews, and letters to the editor.
Our purpose is to publish a prestigious international journal for studies in integrative medicine. To achieve this aim, we seek to publish high-quality papers on any aspects of integrative medicine, such as acupuncture and traditional Chinese medicine, Ayurveda medicine, herbal medicine, homeopathy, nutrition, chiropractic, mind-body medicine, taichi, qigong, meditation, and any other modalities of CAM; our commitment to international scope ensures that research and progress from all regions of the world are widely covered. These ensure that articles published in JIM have the maximum exposure to the international scholarly community.
JIM can help its authors let their papers reach the widest possible range of readers, and let all those who share an interest in their research field be concerned with their study.
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