被确定为血清中新型生物标记物的 FOXN2 通过与分割缺陷 6 同源物 alpha 的相互作用调节转化生长因子-β 信号通路，从而促进胃癌的发病机制

IF 1.8 4区生物学 Q4 CELL BIOLOGY

Growth factors Pub Date : 2024-03-04 DOI:10.1080/08977194.2023.2297700

Liang Li, XueFeng Sun, Mei Zhang, BangShuo Zhang, Yi Yang, Sheng Wang

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引用次数: 0

摘要

在多种癌症类型中都发现了叉头盒N2（FOXN2）的表达失调。然而，FOXN2导致胃癌发病和进展的潜在机制是什么？

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FOXN2, identified as a novel biomarker in serum, modulates the transforming growth factor-beta signaling pathway through its interaction with partitioning defective 6 homolog alpha, contributing to the pathogenesis of gastric cancer

Dysregulated expression of Forkhead Box N2 (FOXN2) has been detected in various cancer types. However, the underlying mechanisms by which FOXN2 contributes to the onset and progression of gastric c...

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来源期刊

Growth factors 生物-内分泌学与代谢

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Growth Factors is an international and interdisciplinary vehicle publishing new knowledge and findings on the regulators of cell proliferation, differentiation and survival. The Journal will publish research papers, short communications and reviews on current developments in cell biology, biochemistry, physiology or pharmacology of growth factors, cytokines or hormones which improve our understanding of biology or medicine. Among the various fields of study topics of particular interest include: •Stem cell biology •Growth factor physiology •Structure-activity relationships •Drug development studies •Clinical applications