含二硫化物的免疫调节剂 Molixan 对青蛙皮肤上皮细胞 Na+ 转运的影响

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology

Biophysics Pub Date : 2024-03-07 DOI:10.1134/S0006350923050172

A. V. Melnitskaya, Z. I. Krutetskaya, V. G. Antonov, N. I. Krutetskaya

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引用次数: 0

摘要

摘要研究了氧化谷胱甘肽的药理类似物--含二硫化物的免疫调节剂molixan对蛙皮肤上皮细胞Na+转运的影响。利用电压钳法，研究人员首次发现了莫利生对蛙皮肤上皮细胞中 Na+ 转运的调节作用。研究发现，从皮肤顶端加入莫利克散会抑制 Na+ 转运，而从基底侧加入时，莫利克散会模拟胰岛素的作用，刺激 Na+ 转运。结果表明，氧化谷胱甘肽及其药理类似物莫立克散和谷维素能单向调节蛙皮肤的 Na+ 转运。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The Effect of Molixan, a Disulfide-Containing Immunomodulator, on Na+ Transport across Frog Skin Epithelium

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The Effect of Molixan, a Disulfide-Containing Immunomodulator, on Na+ Transport across Frog Skin Epithelium

The effect of the pharmacological analogue of oxidized glutathione, disulfide-containing immunomodulator molixan, on the Na⁺ transport in the frog skin epithelium was studied. Using the voltage-clamp method, it was shown for the first time that molixan modulated Na⁺ transport in the frog skin epithelium. It was found that the application of molixan from the apical surface of the skin suppressed Na⁺ transport, whereas when added from the basolateral surface, molixan mimicked the action of insulin and stimulated Na⁺ transport. The results indicate that oxidized glutathione and its pharmacological analogues molixan and glutoxim unidirectionally modulate Na⁺ transport in frog skin.

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来源期刊

Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.