A20：万事通。

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-05-01 Epub Date: 2024-03-09 DOI:10.1016/j.tcb.2024.02.008

Pieter Hertens, Geert van Loo

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引用次数: 0

摘要

A20/TNFAIP3 的突变和多态性与各种炎症性疾病有关。然而，除了在炎症中发挥众所周知的作用外，A20 还能控制 EDAR 和 NF-κB 受体激活剂（RANK）诱导的 NF-κB 信号传导，分别调节表皮皮肤附属物和骨骼的发育。此外，A20 还通过一种依赖于 NF-κB 的机制来调节突触重塑。

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A20: a jack of all trades.

Mutations and polymorphisms in A20/TNFAIP3 have been linked to various inflammatory disorders. However, in addition to its well-known role in inflammation, A20 also controls EDAR- and receptor activator of NF-κB (RANK)-induced NF-κB signaling, regulating the development of epidermal skin appendages and bone, respectively. Furthermore, A20 regulates synapse remodeling through a mechanism dependent on NF-κB.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.