肝硬化失代偿期患者低血清 25-羟维生素 D [25(OH) d] 与肝性脑病的关系。

IF 1.1 4区 医学 Q4 GASTROENTEROLOGY & HEPATOLOGY
Abdul Mumit Sarkar , Abdullah Al Mukit , Tanzilul Bari , Rofiqul Islam , Shafiqul Islam , Khalequzzaman Sarker , Manzurul Chowdhury , Mohd. Harun Or Rashid , Abdul Alim
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引用次数: 0

摘要

背景和研究目的:肝性脑病的发病机制十分复杂,尚未得到最终证实。最近的研究支持肝性脑病患者血清 25-羟基维生素 D [25(OH) D] 水平较低。本研究旨在评估肝硬化失代偿期患者血清 25(OH)D 与肝性脑病之间的关系:本研究共招募了 70 名肝硬化患者(35 名肝性脑病患者和 35 名无脑病对照组患者,平均年龄(53.07 ± 12.99)岁,67% 为男性)。肝硬化严重程度的评估采用终末期肝病模型(MELD)和Child Turcotte Pugh(CTP)评分,肝性脑病严重程度的评估采用West Haven标准。血清25(OH)D水平通过化学发光微粒子免疫测定(CMIA)进行测量:结果:肝性脑病患者的平均血清 25(OH)D 水平明显低于无脑病的对照组(18.76 ± 8.84 nmol/L vs 31.19 ± 13.9 nmol/L,PC):研究发现,血清25(OH)D水平低与肝性脑病之间存在明显关联。需要进一步开展大规模多中心研究,将其确定为肝性脑病的风险因素和预测因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of low serum 25-Hydroxy vitamin D [25(OH) d] with hepatic encephalopathy in patients with decompensated liver cirrhosis

Background and study aims

The mechanism of hepatic encephalopathy is complex and has not been conclusively established. Recent studies support lower serum 25-Hydroxy Vitamin D [25(OH) D] levels in patients with hepatic encephalopathy. This study aimed to evaluate the association between serum 25(OH) D and hepatic encephalopathy in patients with decompensated cirrhosis of liver.

Patients and methods

A total of 70 cirrhosis patients (35 cases of hepatic encephalopathy and 35 patients without encephalopathy as control, mean age 53.07 ± 12.99 years, 67 % male) were recruited for this study. Assessment of the severity of cirrhosis was done by using a model for end-stage liver disease(MELD) and Child Turcotte Pugh (CTP) scores, and assessment of the severity of hepatic encephalopathy was done according to West Haven criteria. Serum 25 (OH) D level was measured by Chemiluminescent Microparticle Immuno Assay(CMIA).

Results

The mean serum 25(OH) D level among hepatic encephalopathy patients was significantly lower in comparison to the control group without encephalopathy (18.76 ± 8.84 nmol/L vs 31.19 ± 13.9 nmol/L, P<0.0001). 91.4 % of hepatic encephalopathy patients had moderate to severe 25(OH)D deficiency as compared to 51.4 % in the control group. There was a significant correlation observed between the severity of the 25 (OH) D deficiency and the severity of liver disease (r =  − 0.35, P = 0.002). No statistically significant difference in serum 25(OH) D levels was found among patients with different hepatic encephalopathy grades (P = 0.416).

Conclusion

A significant association was found between a low serum 25(OH) D leveland hepatic encephalopathy. It requires further large-scale multicenter studies to establish it as a risk factor and predictor of hepatic encephalopathy.

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来源期刊
Arab Journal of Gastroenterology
Arab Journal of Gastroenterology Medicine-Gastroenterology
CiteScore
2.70
自引率
0.00%
发文量
52
期刊介绍: Arab Journal of Gastroenterology (AJG) publishes different studies related to the digestive system. It aims to be the foremost scientific peer reviewed journal encompassing diverse studies related to the digestive system and its disorders, and serving the Pan-Arab and wider community working on gastrointestinal disorders.
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