研究益生菌对预防旅行者腹泻的影响:基于元分析的系统综述。

IF 6.3 3区 医学 Q1 INFECTIOUS DISEASES
Basmah F. Alharbi , Abeer A. Alateek
{"title":"研究益生菌对预防旅行者腹泻的影响:基于元分析的系统综述。","authors":"Basmah F. Alharbi ,&nbsp;Abeer A. Alateek","doi":"10.1016/j.tmaid.2024.102703","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Approximately 10–40 million travelers get Traveler's Diarrhea (TD) yearly. A significant decrease in TD incidence has not been achieved by depending solely on antibiotic prophylaxis and educational initiatives. Using prebiotics to prevent TD has also not been examined in previous evaluations of probiotics for TD, which failed to consider the strain-specificity of probiotic efficacy. This review investigates the overall effects of probiotics on preventing TD, including the impact of dosage, duration, and age.</p></div><div><h3>Methods</h3><p>Standard literature databases were searched without restriction on publication year or language. The following criteria are included: randomized controlled trials (RCTs) in English or non-English unrestricted to publication year, excluding animal and observational studies. This systematic review applied the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.</p></div><div><h3>Results</h3><p>Of the 166 screened papers, 10 RCTs were included. <em>Lactobacillus acidophilus</em> showed no efficacy in preventing TD except when mixed with other strains. Other genera of <em>lactobacilli</em> showed a protection rate of up to 39% against TD. Similarly, <em>Saccharomyces cerevisiae</em> and <em>Saccharomyces boulardii</em> have been effective in preventing TD.</p></div><div><h3>Conclusion</h3><p>Studies investigating probiotics as a preventive measure for TD remain limited. Only a few probiotics that reduce TD risk exist. Based on this systematic review and meta-analysis, specific probiotic strains, including <em>L. acidophilus, L. rhamnosus, L. fermentum, S. cerevisiae,</em> and <em>S. boulardii</em>, may prevent TD. The effect of additional probiotic strains on TD prevention must be further investigated.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"59 ","pages":"Article 102703"},"PeriodicalIF":6.3000,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000176/pdfft?md5=20ef85eb062ebd2be4fbe400efa33584&pid=1-s2.0-S1477893924000176-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review\",\"authors\":\"Basmah F. Alharbi ,&nbsp;Abeer A. Alateek\",\"doi\":\"10.1016/j.tmaid.2024.102703\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Approximately 10–40 million travelers get Traveler's Diarrhea (TD) yearly. A significant decrease in TD incidence has not been achieved by depending solely on antibiotic prophylaxis and educational initiatives. Using prebiotics to prevent TD has also not been examined in previous evaluations of probiotics for TD, which failed to consider the strain-specificity of probiotic efficacy. This review investigates the overall effects of probiotics on preventing TD, including the impact of dosage, duration, and age.</p></div><div><h3>Methods</h3><p>Standard literature databases were searched without restriction on publication year or language. The following criteria are included: randomized controlled trials (RCTs) in English or non-English unrestricted to publication year, excluding animal and observational studies. This systematic review applied the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.</p></div><div><h3>Results</h3><p>Of the 166 screened papers, 10 RCTs were included. <em>Lactobacillus acidophilus</em> showed no efficacy in preventing TD except when mixed with other strains. Other genera of <em>lactobacilli</em> showed a protection rate of up to 39% against TD. Similarly, <em>Saccharomyces cerevisiae</em> and <em>Saccharomyces boulardii</em> have been effective in preventing TD.</p></div><div><h3>Conclusion</h3><p>Studies investigating probiotics as a preventive measure for TD remain limited. Only a few probiotics that reduce TD risk exist. Based on this systematic review and meta-analysis, specific probiotic strains, including <em>L. acidophilus, L. rhamnosus, L. fermentum, S. cerevisiae,</em> and <em>S. boulardii</em>, may prevent TD. The effect of additional probiotic strains on TD prevention must be further investigated.</p></div>\",\"PeriodicalId\":23312,\"journal\":{\"name\":\"Travel Medicine and Infectious Disease\",\"volume\":\"59 \",\"pages\":\"Article 102703\"},\"PeriodicalIF\":6.3000,\"publicationDate\":\"2024-03-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1477893924000176/pdfft?md5=20ef85eb062ebd2be4fbe400efa33584&pid=1-s2.0-S1477893924000176-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Travel Medicine and Infectious Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1477893924000176\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Travel Medicine and Infectious Disease","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1477893924000176","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

摘要

简介每年约有 1,000 万至 4,000 万旅行者患上旅行者腹泻(TD)。仅靠抗生素预防和教育活动并不能明显降低旅行腹泻的发病率。在以往对益生菌治疗旅行者腹泻的评估中,也没有对使用益生菌预防旅行者腹泻进行研究,因为这些评估没有考虑益生菌功效的菌株特异性。本综述调查了益生菌对预防TD的总体效果,包括剂量、持续时间和年龄的影响:方法:检索标准文献数据库,不限制发表年份或语言。纳入标准如下:不限发表年份的英语或非英语随机对照试验(RCT),不包括动物实验和观察性研究。本系统综述采用了《系统综述和元分析首选报告项目》(Preferred Reporting Items for Systematic Reviews and Meta-Analyses):结果:在筛选出的 166 篇论文中,纳入了 10 篇研究性试验。除与其他菌株混合使用外,嗜酸乳杆菌在预防TD方面没有任何疗效。其他乳酸菌属对 TD 的保护率高达 39%。同样,酵母菌和布拉氏酵母菌也能有效预防 TD:结论:将益生菌作为 TD 预防措施的研究仍然有限。只有少数益生菌能降低 TD 风险。根据本系统综述和荟萃分析,特定的益生菌菌株,包括嗜酸乳杆菌、鼠李糖杆菌、发酵乳杆菌、葡萄球菌和布拉氏酵母菌,可预防 TD。必须进一步研究其他益生菌株对预防 TD 的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review

Introduction

Approximately 10–40 million travelers get Traveler's Diarrhea (TD) yearly. A significant decrease in TD incidence has not been achieved by depending solely on antibiotic prophylaxis and educational initiatives. Using prebiotics to prevent TD has also not been examined in previous evaluations of probiotics for TD, which failed to consider the strain-specificity of probiotic efficacy. This review investigates the overall effects of probiotics on preventing TD, including the impact of dosage, duration, and age.

Methods

Standard literature databases were searched without restriction on publication year or language. The following criteria are included: randomized controlled trials (RCTs) in English or non-English unrestricted to publication year, excluding animal and observational studies. This systematic review applied the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

Results

Of the 166 screened papers, 10 RCTs were included. Lactobacillus acidophilus showed no efficacy in preventing TD except when mixed with other strains. Other genera of lactobacilli showed a protection rate of up to 39% against TD. Similarly, Saccharomyces cerevisiae and Saccharomyces boulardii have been effective in preventing TD.

Conclusion

Studies investigating probiotics as a preventive measure for TD remain limited. Only a few probiotics that reduce TD risk exist. Based on this systematic review and meta-analysis, specific probiotic strains, including L. acidophilus, L. rhamnosus, L. fermentum, S. cerevisiae, and S. boulardii, may prevent TD. The effect of additional probiotic strains on TD prevention must be further investigated.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Travel Medicine and Infectious Disease
Travel Medicine and Infectious Disease PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-INFECTIOUS DISEASES
CiteScore
19.40
自引率
1.70%
发文量
211
审稿时长
49 days
期刊介绍: Travel Medicine and Infectious Disease Publication Scope: Publishes original papers, reviews, and consensus papers Primary theme: infectious disease in the context of travel medicine Focus Areas: Epidemiology and surveillance of travel-related illness Prevention and treatment of travel-associated infections Malaria prevention and treatment Travellers' diarrhoea Infections associated with mass gatherings Migration-related infections Vaccines and vaccine-preventable disease Global policy/regulations for disease prevention and control Practical clinical issues for travel and tropical medicine practitioners Coverage: Addresses areas of controversy and debate in travel medicine Aims to inform guidelines and policy pertinent to travel medicine and the prevention of infectious disease Publication Features: Offers a fast peer-review process Provides early online publication of accepted manuscripts Aims to publish cutting-edge papers
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信