强迫症中的炎症:文献综述和基于假设的经颅光生物调制潜力。

IF 2.9 3区 医学 Q2 NEUROSCIENCES
David Richer Araujo Coelho, Joshua D. Salvi, Willians Fernando Vieira, Paolo Cassano
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引用次数: 0

摘要

强迫症(OCD)是一种致残性神经精神障碍,约占全球人口的 2%-3%。尽管有多种治疗方法,但许多强迫症患者的反应并不充分,这凸显了对新治疗方法的需求。最近的研究表明,各种炎症过程与强迫症的发病机制有关,包括外周免疫细胞的改变、细胞因子水平的改变和神经炎症。这些研究结果表明,炎症可能是一个很有希望的干预目标。利用近红外线进行经颅光生物调制(t-PBM)是一种非侵入性神经调制技术,已显示出治疗多种神经精神疾病的潜力。然而,它对强迫症的疗效仍有待充分探索。本研究旨在回顾有关强迫症炎症的文献,详细阐述与 T 细胞群、单核细胞、NLRP3 炎性体成分、小胶质细胞活化以及 TNF-α、CRP、IL-1β 和 IL-6 等促炎细胞因子升高的关联。我们还研究了 t-PBM 在靶向这些强迫症炎症通路方面的假设潜力,重点研究了氧化应激调节、免疫细胞功能调节、促炎细胞因子水平降低、神经毒性小胶质细胞失活和 BDNF 基因表达上调等机制。我们的综述表明,t-PBM 可能是治疗强迫症的一种很有前景的非侵入性干预方法,具有调节潜在炎症过程的潜力。未来的研究应侧重于随机临床试验,以评估 t-PBM 对强迫症的疗效和最佳治疗参数。生物标志物分析和神经影像学研究对于了解炎症调节与 t-PBM 治疗后强迫症症状改善之间的关系非常重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inflammation in obsessive–compulsive disorder: A literature review and hypothesis-based potential of transcranial photobiomodulation

Obsessive–compulsive disorder (OCD) is a disabling neuropsychiatric disorder that affects about 2%–3% of the global population. Despite the availability of several treatments, many patients with OCD do not respond adequately, highlighting the need for new therapeutic approaches. Recent studies have associated various inflammatory processes with the pathogenesis of OCD, including alterations in peripheral immune cells, alterations in cytokine levels, and neuroinflammation. These findings suggest that inflammation could be a promising target for intervention. Transcranial photobiomodulation (t-PBM) with near-infrared light is a noninvasive neuromodulation technique that has shown potential for several neuropsychiatric disorders. However, its efficacy in OCD remains to be fully explored. This study aimed to review the literature on inflammation in OCD, detailing associations with T-cell populations, monocytes, NLRP3 inflammasome components, microglial activation, and elevated proinflammatory cytokines such as TNF-α, CRP, IL-1β, and IL-6. We also examined the hypothesis-based potential of t-PBM in targeting these inflammatory pathways of OCD, focusing on mechanisms such as modulation of oxidative stress, regulation of immune cell function, reduction of proinflammatory cytokine levels, deactivation of neurotoxic microglia, and upregulation of BDNF gene expression. Our review suggests that t-PBM could be a promising, noninvasive intervention for OCD, with the potential to modulate underlying inflammatory processes. Future research should focus on randomized clinical trials to assess t-PBM's efficacy and optimal treatment parameters in OCD. Biomarker analyses and neuroimaging studies will be important in understanding the relationship between inflammatory modulation and OCD symptom improvement following t-PBM sessions.

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来源期刊
Journal of Neuroscience Research
Journal of Neuroscience Research 医学-神经科学
CiteScore
9.50
自引率
2.40%
发文量
145
审稿时长
1 months
期刊介绍: The Journal of Neuroscience Research (JNR) publishes novel research results that will advance our understanding of the development, function and pathophysiology of the nervous system, using molecular, cellular, systems, and translational approaches. JNR covers both basic research and clinical aspects of neurology, neuropathology, psychiatry or psychology. The journal focuses on uncovering the intricacies of brain structure and function. Research published in JNR covers all species from invertebrates to humans, and the reports inform the readers about the function and organization of the nervous system, with emphasis on how disease modifies the function and organization.
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