药物化学和化学生物学中的光化学。

IF 6.8 1区医学 Q1 CHEMISTRY, MEDICINAL

Journal of Medicinal Chemistry Pub Date : 2024-03-08 DOI:10.1021/acs.jmedchem.3c02109

W. Felix Zhu, Claire Empel, Sveva Pelliccia, Rene M. Koenigs*, Ewgenij Proschak* and Victor Hernandez-Olmos*,

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引用次数: 0

摘要

光化学已成为有机化学的变革力量，极大地拓展了药物化学的化学空间。光诱导反应能够高效合成复杂的有机结构，在药物发现和开发过程的不同阶段都有应用。此外，光化学技术还为化学生物学提供了创新解决方案，可实现精确的时空药物激活和靶向给药。在本《视角》中，我们将重点介绍光化学在药物化学和化学生物学中已经取得的众多卓越应用，以及更加充满希望的未来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Photochemistry in Medicinal Chemistry and Chemical Biology

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Photochemistry in Medicinal Chemistry and Chemical Biology

Photochemistry has emerged as a transformative force in organic chemistry, significantly expanding the chemical space accessible for medicinal chemistry. Light-induced reactions enable the efficient synthesis of intricate organic structures and have found applications throughout the different stages of the drug discovery and development processes. Moreover, photochemical techniques provide innovative solutions in chemical biology, allowing precise spatiotemporal drug activation and targeted delivery. In this Perspective, we highlight the already numerous remarkable applications and the even more promising future of photochemistry in medicinal chemistry and chemical biology.

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来源期刊

Journal of Medicinal Chemistry 医学-医药化学

CiteScore

4.00

自引率

11.00%

发文量

804

审稿时长

1.9 months

期刊介绍： The Journal of Medicinal Chemistry is a prestigious biweekly peer-reviewed publication that focuses on the multifaceted field of medicinal chemistry. Since its inception in 1959 as the Journal of Medicinal and Pharmaceutical Chemistry, it has evolved to become a cornerstone in the dissemination of research findings related to the design, synthesis, and development of therapeutic agents. The Journal of Medicinal Chemistry is recognized for its significant impact in the scientific community, as evidenced by its 2022 impact factor of 7.3. This metric reflects the journal's influence and the importance of its content in shaping the future of drug discovery and development. The journal serves as a vital resource for chemists, pharmacologists, and other researchers interested in the molecular mechanisms of drug action and the optimization of therapeutic compounds.