研究蝙蝠免疫的转化潜力。

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2024-03-01 Epub Date: 2024-03-06 DOI:10.1016/j.it.2024.01.007

Kaushal Baid, Aaron T Irving, Nolwenn Jouvenet, Arinjay Banerjee

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引用次数: 0

摘要

通过对蝙蝠的分子研究，我们发现了蝙蝠的抗病毒适应性，这些适应性可以解释一些蝙蝠物种是如何进化出对病毒更强的免疫耐受能力的。不断积累的数据表明，一些蝙蝠物种还进化出了长寿和低癌症发病率的显著特征。此外，最近的研究有力地表明，在蝙蝠模型中发现免疫适应性可以转化为开发免疫调节剂和识别影响人类疾病的替代治疗策略。我们认为，蝙蝠免疫学研究将带来一些发现，这些发现有可能被转化为改善人类健康状况的方法。

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The translational potential of studying bat immunity.

Molecular studies in bats have led to the discovery of antiviral adaptations that may explain how some bat species have evolved enhanced immune tolerance towards viruses. Accumulating data suggest that some bat species have also evolved remarkable features of longevity and low rates of cancer. Furthermore, recent research strongly suggests that discovering immune adaptations in bat models can be translated to develop immune modulators and recognize alternate therapeutic strategies for diseases affecting humans. We posit that research in bat immunology will lead to discoveries that can potentially be translated to improve health outcomes in humans.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.