TM9SF1 与促进膀胱癌细胞的增殖和侵袭有关。

IF 2.6 Q3 ONCOLOGY

World journal of clinical oncology Pub Date : 2024-02-24 DOI:10.5306/wjco.v15.i2.175

Shu-Qing Zhou, Lian-Xiang Luo

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引用次数: 0

摘要

Zhuo等人研究了跨膜9超家族成员1（TM9SF1）在膀胱癌（BC）中的作用，并评估了它是否可用作治疗靶点。他们创建了一种永久性膀胱癌细胞系，并测试了TM9SF1过表达和抑制对膀胱癌细胞生长、移动、侵袭和细胞周期进展的影响。结果表明，TM9SF1能促进BC细胞的生长、移动和侵袭，并使其进入细胞周期的G2/M阶段。这项研究为BC的靶向治疗提供了一个新的方向和概念。

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TM9SF1 is implicated in promoting the proliferation and invasion of bladder cancer cells.

Zhuo et al looked into the part of transmembrane 9 superfamily member 1 (TM9SF1) in bladder cancer (BC), and evaluated if it can be used as a therapeutic target. They created a permanent BC cell line and tested the effects of TM9SF1 overexpression and suppression on BC cell growth, movement, invasion, and cell cycle advancement. Their results show that TM9SF1 can boost the growth, movement, and invasion of BC cells and their access into the G2/M stage of the cell cycle. This research gives a novel direction and concept for targeted therapy of BC.

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来源期刊

World journal of clinical oncology ONCOLOGY-

自引率

0.00%

发文量

585

期刊介绍： The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.