乳腺癌中的 KMT2C 和 KMT2D 畸变。

IF 14.3 1区 医学 Q1 ONCOLOGY
Trends in cancer Pub Date : 2024-06-01 Epub Date: 2024-03-07 DOI:10.1016/j.trecan.2024.02.003
Emily Tinsley, Philip Bredin, Sinead Toomey, Bryan T Hennessy, Simon J Furney
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引用次数: 0

摘要

KMT2C 和 KMT2D 是组蛋白赖氨酸甲基转移酶,负责对基因增强子位点的组蛋白 3 赖氨酸 4 (H3K4) 残基进行单甲基化。KMT2C/D 是乳腺癌中最常发生突变的组蛋白甲基转移酶(HMTs),发生频率合计为 10-20%。频繁发生的损伤性和截断性体细胞突变表明,KMT2C/D 在乳腺癌发生过程中起着抑制肿瘤的作用。最近利用细胞系和小鼠模型复制 KMT2C/D 缺失的研究表明,这些基因通过启动基因增强子区域,在 ER+ 乳腺癌中有助于雌激素受体(ER)驱动的转录。本综述概述了 KMT2C/D 的功能,并概述了 KMT2C 和 KMT2D 在乳腺癌发展中作用的最新临床和实验证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
KMT2C and KMT2D aberrations in breast cancer.

KMT2C and KMT2D are histone lysine methyltransferases responsible for the monomethylation of histone 3 lysine 4 (H3K4) residues at gene enhancer sites. KMT2C/D are the most frequently mutated histone methyltransferases (HMTs) in breast cancer, occurring at frequencies of 10-20% collectively. Frequent damaging and truncating somatic mutations indicate a tumour-suppressive role of KMT2C/D in breast oncogenesis. Recent studies using cell lines and mouse models to replicate KMT2C/D loss show that these genes contribute to oestrogen receptor (ER)-driven transcription in ER+ breast cancers through the priming of gene enhancer regions. This review provides an overview of the functions of KMT2C/D and outlines the recent clinical and experimental evidence of the roles of KMT2C and KMT2D in breast cancer development.

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来源期刊
Trends in cancer
Trends in cancer Medicine-Oncology
CiteScore
28.50
自引率
0.50%
发文量
138
期刊介绍: Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.
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