Emma Karjalainen, Mika Niemelä, Helinä Hakko, Karl-Erik Wahlberg, Sami Räsänen
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引用次数: 0
摘要
背景和目的:有证据表明,精神分裂症患者的后代躯体发病率较高,其部分原因被认为是躯体疾病与精神分裂症之间存在遗传联系。本研究探讨了精神分裂症谱系障碍高遗传风险(HR)或低遗传风险(LR)的被收养者在躯体疾病和病症方面的差异:本研究是芬兰精神分裂症收养家庭研究的一部分。采用领养研究设计,可以考察在类似领养家庭中长大的被领养者的躯体健康如何受到精神分裂症遗传易感性的影响。研究样本包括 373 名被收养者,其中 190 人患有 HR,183 人患有精神分裂症谱系障碍 LR。有关躯体发病率的数据来自医院记录以及全国医疗保健登记册和社会保险机构登记册:唯一具有统计学意义的差异出现在泌尿生殖系统疾病方面,与LR收养者相比,HR收养者患病的可能性高出两倍(16.8% vs. 8.2%;adj. OR = 2.13,95% CI 1.06-4.25,p = .033)。女性和年龄超过40岁的被收养者患泌尿生殖系统疾病的比例高于非被收养者:结论:在有精神分裂症谱系障碍风险的被收养者中,泌尿生殖系统疾病的发病率很高,这表明一些特定的躯体疾病和精神分裂症可能有共同的遗传病因。需要对研究人群中的特定躯体疾病进行更多研究,以区分遗传和环境因素的影响。
The Finnish Adoptive Family Study of Schizophrenia: differences in somatic diseases and conditions between adoptees with high or low genetic risk for schizophrenia spectrum disorders.
Background and aims: There is some evidence that offspring of patients with schizophrenia have higher somatic morbidity, which is thought to be partially due to genetic links between somatic disorders and schizophrenia. This study explored differences in somatic diseases and conditions of adoptees with high genetic risk (HR) or low genetic risk (LR) for schizophrenia spectrum disorders.
Material and methods: The study is part of the Finnish Adoptive Family Study of Schizophrenia. The adoptive research design used made it possible to examine how the somatic health of adoptees raised in similar adoptive families, is affected by their genetic susceptibility to schizophrenia. The study sample consisted of 373 adoptees, of whom 190 had HR and 183 had LR for schizophrenia spectrum disorders. Data on somatic morbidity were gathered from the hospital records and from the national registers of the Care Register of Health Care and the Social Insurance Institution.
Results: The only statistically significant difference found was in genitourinary diseases, the likelihood being twofold higher in HR adoptees compared to LR adoptees (16.8% vs. 8.2%; adj. OR = 2.13, 95% CI 1.06-4.25, p = .033). Adoptees who were female and aged over 40 had a higher prevalence of genitourinary illnesses than non-adoptees.
Conclusion: The significant prevalence of genitourinary diseases in adoptees at risk for schizophrenia spectrum disorders suggests that some specific somatic diseases and schizophrenia may have a shared hereditary etiology. More research is required for specific somatic diseases in study populations that can differentiate between the effects of genetic and environmental factors.
期刊介绍:
Nordic Journal of Psychiatry publishes international research on all areas of psychiatry.
Nordic Journal of Psychiatry is the official journal for the eight psychiatry associations in the Nordic and Baltic countries. The journal aims to provide a leading international forum for high quality research on all themes of psychiatry including:
Child psychiatry
Adult psychiatry
Psychotherapy
Pharmacotherapy
Social psychiatry
Psychosomatic medicine
Nordic Journal of Psychiatry accepts original research articles, review articles, brief reports, editorials and letters to the editor.