凤凰动物园黑脚貂(mustela nigripes)肾脏疾病诊断血液分析物的诊断性能(2001-2020 年)。

IF 0.7 4区 农林科学 Q3 VETERINARY SCIENCES
Alyssa G Palmer, Nicole I Stacy, Jorge A Hernandez, Alexandra Goe
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引用次数: 0

摘要

肾脏疾病是黑脚雪貂(BFF;Mustela nigripes)发病和死亡的重要原因。4,6,12 本研究的目的是确定临床正常黑脚雪貂(1-2 岁)血液分析物的参考区间,总结管理黑脚雪貂群体中各种肾脏组织病理学发现的频率,评估血液分析物和尿液比重(USG)诊断肾脏疾病的性能,以及评估合并症或年龄是否会影响这些分析物诊断肾脏疾病的性能。参考区间是通过一组临床正常的年轻成年 BFF(n = 35)确定的。我们查阅了凤凰城动物园 2001 年至 2020 年间所有 BFF 的尸检记录,并纳入了死亡后 2 周内有血液分析物数据的 BFF(n = 89)。根据尸体解剖后组织病理学异常的器官位置,将雪貂分为三组:以肾脏疾病为主要变化的组;肾脏疾病和至少一个其他主要器官系统受影响的组;肾脏无异常的组。在肾脏发生重大变化的雪貂(39 只中有 29 只,占 74.4%)中,主要诊断为淀粉样变性。肌酐、血尿素氮、磷 (P)、钙 (Ca)、钙磷比、USG、球蛋白和胆固醇是诊断肾病效果最好的分析指标,曲线下面积至少为 0.90 (95% CI $ 0.80, 1.00)。在没有肾脏病组织学证据的死亡 BFF 中,血清肾脏标记物在参考区间内。在死于肾病的动物中,几种血液分析物受年龄的影响很大。这项研究提供了临床正常的年轻成年BFF血液分析指标的参考区间,并说明了该物种肾脏疾病诊断的临床实用性,尤其是肌酐、USG和P。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
DIAGNOSTIC PERFORMANCE OF BLOOD ANALYTES FOR THE DIAGNOSIS OF RENAL DISEASE IN BLACK-FOOTED FERRETS (MUSTELA NIGRIPES) AT THE PHOENIX ZOO (2001-2020).

Renal disease is an important cause of morbidity and mortality in managed black-footed ferrets (BFF; Mustela nigripes).4,6,12 The objectives of this study were to establish reference intervals for blood analytes of clinically normal BFF (1-2 yr old), summarize the frequency of various renal histopathologic findings in a managed population of BFF, assess the diagnostic performance of blood analytes and urine specific gravity (USG) for the diagnosis of renal disease, and assess if comorbidities or age affects the performance of these analytes in diagnosing renal disease. Reference intervals were established using a cohort (n = 35) of clinically normal, young adult BFF. Postmortem records for all BFF at the Phoenix Zoo between 2001 and 2020 were reviewed, and those with available blood analyte data within 2 wk of death were included (n = 89). Ferrets were placed into one of three groups, based on the organ location of histopathologic abnormalities following necropsy: renal disease as the primary change; those with renal disease and at least one other affected major organ system; or absence of abnormalities in the kidneys. In ferrets with substantial renal changes, the primary diagnosis was amyloidosis (29 of 39; 74.4%). Creatinine, blood urea nitrogen, phosphorus (P), calcium (Ca), Ca:P ratio, USG, globulins, and cholesterol were the best-performing analytes for the diagnosis of renal disease, with an area under the curve of at least 0.90 (95% CI $ 0.80, 1.00). Serum renal markers were within reference intervals in BFF that died without histologic evidence of renal disease. Several blood analytes were significantly affected by age in animals that died of renal disease. This study provides reference intervals for blood analytes in young adult clinically normal BFF and illustrates the clinical utility for the diagnosis of renal disease in this species, particularly creatinine, USG, and P.

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来源期刊
Journal of Zoo and Wildlife Medicine
Journal of Zoo and Wildlife Medicine 农林科学-兽医学
CiteScore
1.70
自引率
14.30%
发文量
74
审稿时长
9-24 weeks
期刊介绍: The Journal of Zoo and Wildlife Medicine (JZWM) is considered one of the major sources of information on the biology and veterinary aspects in the field. It stems from the founding premise of AAZV to share zoo animal medicine experiences. The Journal evolved from the long history of members producing case reports and the increased publication of free-ranging wildlife papers. The Journal accepts manuscripts of original research findings, case reports in the field of veterinary medicine dealing with captive and free-ranging wild animals, brief communications regarding clinical or research observations that may warrant publication. It also publishes and encourages submission of relevant editorials, reviews, special reports, clinical challenges, abstracts of selected articles and book reviews. The Journal is published quarterly, is peer reviewed, is indexed by the major abstracting services, and is international in scope and distribution. Areas of interest include clinical medicine, surgery, anatomy, radiology, physiology, reproduction, nutrition, parasitology, microbiology, immunology, pathology (including infectious diseases and clinical pathology), toxicology, pharmacology, and epidemiology.
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