Shahanavaj Khan, S Needa Mosvi, Saeed Vohra, Nitesh Kumar Poddar
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Combination therapy is considered a more effective approach for treating advanced types of colorectal cancer. Nevertheless, several challenges drastically influence the treatment of cancer, such as individual discrepancy, drug resistance, and stage of cancer, among others. Henceforth, novel preventive, reliable therapeutic modalities are essential to control and reduce the incidence and mortality of colorectal cancer (CRC). The calcium-sensing receptor (CaSR) plays a pivotal role in calcium homeostasis, metabolism, and regulation of oncogenesis. Numerous studies have underscored the potential of CaSR, a G protein-coupled receptor, as a potential biomarker and target for colorectal cancer prevention and treatment. The multifaceted involvement of CaSR in anti-inflammatory and anti-carcinogenic processes paves the way for its utilization in the diagnosis and management of colorectal cancer. The current review highlights the important role of supplemental calcium in overall health and disease, along with the exploration of intricate mechanisms of CaSR pathways in the management and prevention of colorectal cancer.</p>","PeriodicalId":10760,"journal":{"name":"Critical reviews in clinical laboratory sciences","volume":null,"pages":null},"PeriodicalIF":6.6000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Implication of calcium supplementations in health and diseases with special focus on colorectal cancer.\",\"authors\":\"Shahanavaj Khan, S Needa Mosvi, Saeed Vohra, Nitesh Kumar Poddar\",\"doi\":\"10.1080/10408363.2024.2322565\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Calcium is a fundamental and integrative element and helps to ensure optimal health by regulating various physiological and pathological processes. While there is substantiated evidence confirming the beneficial effects of calcium in the treatment, management, and prevention of various health conditions, including cancer, conflicting studies are imperative to acknowledge the potential negative role of calcium supplementation. The studies on calcium supplementation showed that a specific dose can help in the maintenance of good human health, and in the control of different types of diseases, including cancer. Calcium alone and when combined with vitamin D, emerges as a promising therapeutic option for efficiently managing cancer growth, when used with chemotherapy. Combination therapy is considered a more effective approach for treating advanced types of colorectal cancer. Nevertheless, several challenges drastically influence the treatment of cancer, such as individual discrepancy, drug resistance, and stage of cancer, among others. 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引用次数: 0
摘要
钙是一种基本的综合元素,通过调节各种生理和病理过程,有助于确保最佳健康状态。虽然有确凿证据证实钙对治疗、控制和预防包括癌症在内的各种健康状况有益,但相互矛盾的研究也必须承认补钙的潜在负面作用。有关补钙的研究表明,一定剂量的钙有助于维持人体健康,控制包括癌症在内的各种疾病。单独补钙或与维生素 D 结合使用,与化疗一起使用,可有效控制癌症的生长。综合疗法被认为是治疗晚期结直肠癌的更有效方法。然而,个体差异、耐药性和癌症分期等一些挑战极大地影响着癌症的治疗。因此,新型的预防性可靠治疗方法对于控制和降低结直肠癌(CRC)的发病率和死亡率至关重要。钙感应受体(CaSR)在钙平衡、新陈代谢和肿瘤发生调控中发挥着关键作用。大量研究强调了钙传感受体(一种 G 蛋白偶联受体)作为潜在生物标志物和结直肠癌预防与治疗靶点的潜力。CaSR 在抗炎和抗癌过程中的多方面参与为其在结直肠癌诊断和治疗中的应用铺平了道路。本综述强调了补充钙质在整体健康和疾病中的重要作用,同时探讨了 CaSR 通路在管理和预防结直肠癌中的复杂机制。
Implication of calcium supplementations in health and diseases with special focus on colorectal cancer.
Calcium is a fundamental and integrative element and helps to ensure optimal health by regulating various physiological and pathological processes. While there is substantiated evidence confirming the beneficial effects of calcium in the treatment, management, and prevention of various health conditions, including cancer, conflicting studies are imperative to acknowledge the potential negative role of calcium supplementation. The studies on calcium supplementation showed that a specific dose can help in the maintenance of good human health, and in the control of different types of diseases, including cancer. Calcium alone and when combined with vitamin D, emerges as a promising therapeutic option for efficiently managing cancer growth, when used with chemotherapy. Combination therapy is considered a more effective approach for treating advanced types of colorectal cancer. Nevertheless, several challenges drastically influence the treatment of cancer, such as individual discrepancy, drug resistance, and stage of cancer, among others. Henceforth, novel preventive, reliable therapeutic modalities are essential to control and reduce the incidence and mortality of colorectal cancer (CRC). The calcium-sensing receptor (CaSR) plays a pivotal role in calcium homeostasis, metabolism, and regulation of oncogenesis. Numerous studies have underscored the potential of CaSR, a G protein-coupled receptor, as a potential biomarker and target for colorectal cancer prevention and treatment. The multifaceted involvement of CaSR in anti-inflammatory and anti-carcinogenic processes paves the way for its utilization in the diagnosis and management of colorectal cancer. The current review highlights the important role of supplemental calcium in overall health and disease, along with the exploration of intricate mechanisms of CaSR pathways in the management and prevention of colorectal cancer.
期刊介绍:
Critical Reviews in Clinical Laboratory Sciences publishes comprehensive and high quality review articles in all areas of clinical laboratory science, including clinical biochemistry, hematology, microbiology, pathology, transfusion medicine, genetics, immunology and molecular diagnostics. The reviews critically evaluate the status of current issues in the selected areas, with a focus on clinical laboratory diagnostics and latest advances. The adjective “critical” implies a balanced synthesis of results and conclusions that are frequently contradictory and controversial.