控制神经元活动：α-突触核蛋白丝氨酸-129磷酸化在健康大脑中的新作用。

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2024-05-01 DOI:10.1016/j.tibs.2024.02.006

Danielle E. Mor

引用次数: 0

摘要

α-突触核蛋白蛋白在丝氨酸-129（Ser129P）处的磷酸化是神经退行性疾病（突触核蛋白病）中一种广泛使用的病理标记。在 Parra-Rivas、Madhivanan 等人的突破性研究中，Ser129P 被证明能促进 α-synuclein 的正常功能，对从生理状态向病理状态的转变具有重要意义。

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Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain

Phosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by Parra-Rivas, Madhivanan et al., Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

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