2024 年如何管理瓦尔登斯特伦巨球蛋白血症

IF 11.3 1区化学 Q1 CHEMISTRY, PHYSICAL

ACS Catalysis Pub Date : 2024-03-05 DOI:10.1016/j.ctrv.2024.102715

Alexander Grunenberg , Christian Buske

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引用次数: 0

摘要

近年来，由于我们对这种疾病的生物学特性有了更深入的了解，并开发出了新的疗法，瓦尔登斯特伦巨球蛋白血症的临床治疗取得了重大进展。在此基础上，WM 患者有了多种治疗选择，从传统的免疫化疗到阻断淋巴瘤生长关键酶的靶向疗法，不一而足。本综述总结了我们目前对这种罕见但复发性淋巴瘤亚型的诊断和治疗知识，这种淋巴瘤在日常临床生活中往往是一个重大的临床挑战。

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How to manage waldenström’s macroglobulinemia in 2024

Clinical management of Waldenström’s Macroglobulinemia has seen major progress in the recent years, triggered by our improved understanding of the biology of the disease and the development of new therapies. Based on this there are multiple treatment options available for patients with WM ranging from classical immunochemotherapy to targeted approaches blocking key enzymes involved in lymphoma growth. This review summarizes our current knowledge about diagnostics and treatment of this rare but recurrent lymphoma subtype, which often presents a major clinical challenge in daily clinical life.

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.