Pawel Swietach, Marja Jäättelä, Shari Pillon-Thomas, Ebbe Boedtkjer
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引用次数: 0
摘要
癌症新陈代谢会产生大量乳酸和 H+，并通过膜转运体排出体外。然而，H+的产生和排出必须通过扩散耦合，并由移动缓冲器促进。Yan 等人提出，由 CARNS2 生成的肌肽提供了这种移动缓冲，并使溶酶体功能得以实现，从而阻碍了 T 细胞的监控。
Carnosine facilitates lysosomal release of inhibitors of T cell surveillance.
Cancer metabolism produces large fluxes of lactate and H+, which are extruded by membrane transporters. However, H+ production and extrusion must be coupled by diffusion, facilitated by mobile buffers. Yan et al. propose that carnosine, generated by CARNS2, provides this mobile buffering and enables lysosomal functions that block T cell surveillance.
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