肉碱能促进溶酶体释放 T 细胞监视抑制剂。

Pawel Swietach, Marja Jäättelä, Shari Pillon-Thomas, Ebbe Boedtkjer
{"title":"肉碱能促进溶酶体释放 T 细胞监视抑制剂。","authors":"Pawel Swietach, Marja Jäättelä, Shari Pillon-Thomas, Ebbe Boedtkjer","doi":"10.1016/j.cmet.2024.02.003","DOIUrl":null,"url":null,"abstract":"<p><p>Cancer metabolism produces large fluxes of lactate and H<sup>+</sup>, which are extruded by membrane transporters. However, H<sup>+</sup> production and extrusion must be coupled by diffusion, facilitated by mobile buffers. Yan et al. propose that carnosine, generated by CARNS2, provides this mobile buffering and enables lysosomal functions that block T cell surveillance.</p>","PeriodicalId":93927,"journal":{"name":"Cell metabolism","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Carnosine facilitates lysosomal release of inhibitors of T cell surveillance.\",\"authors\":\"Pawel Swietach, Marja Jäättelä, Shari Pillon-Thomas, Ebbe Boedtkjer\",\"doi\":\"10.1016/j.cmet.2024.02.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cancer metabolism produces large fluxes of lactate and H<sup>+</sup>, which are extruded by membrane transporters. However, H<sup>+</sup> production and extrusion must be coupled by diffusion, facilitated by mobile buffers. Yan et al. propose that carnosine, generated by CARNS2, provides this mobile buffering and enables lysosomal functions that block T cell surveillance.</p>\",\"PeriodicalId\":93927,\"journal\":{\"name\":\"Cell metabolism\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.cmet.2024.02.003\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.cmet.2024.02.003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

癌症新陈代谢会产生大量乳酸和 H+,并通过膜转运体排出体外。然而,H+的产生和排出必须通过扩散耦合,并由移动缓冲器促进。Yan 等人提出,由 CARNS2 生成的肌肽提供了这种移动缓冲,并使溶酶体功能得以实现,从而阻碍了 T 细胞的监控。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Carnosine facilitates lysosomal release of inhibitors of T cell surveillance.

Cancer metabolism produces large fluxes of lactate and H+, which are extruded by membrane transporters. However, H+ production and extrusion must be coupled by diffusion, facilitated by mobile buffers. Yan et al. propose that carnosine, generated by CARNS2, provides this mobile buffering and enables lysosomal functions that block T cell surveillance.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信