酗酒与肌肉无力：对患有酒精使用障碍的流动参与者补充维生素 D 的效果进行的原创性研究。

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol Pub Date : 2024-03-05 DOI:10.1016/j.alcohol.2024.03.001

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引用次数: 0

摘要

简介慢性酒精相关肌病表现为近端肌肉无力。我们研究了补充维生素 D 对酒精中毒成人肌无力的影响：方法：随机对照试验。参与者为居住在社区的酒精使用障碍成人。被分配到VIDIO（维生素D强化外展）的参与者每两个月口服50,000-100,000 IU胆钙化醇，为期12个月。被分配到CAU（常规护理）的参与者则接受每天一次的含800 IU胆钙化醇和500毫克碳酸钙的药片处方。数据包括人口统计学变量、实验室测试、饮酒情况以及寻求帮助和支持的评分量表。主要结果是参与者的股四头肌最大自主收缩力（qMVC）和血清-25（OH）维生素D浓度（25（OH）D）：66名参与者中，性别比为50/16，平均年龄为51岁，每周饮酒量中位数为52 [IQR 24-95]杯。基线 qMVC 值为参考值的 77%（SD 29%）。44/66名参与者接受了实验室检测：基线25（OH）D浓度为39.4（标准偏差为23.7）纳摩尔/升。31名参与者的25（OH）D浓度为结论：在维生素治疗期间，qMVC值有所改善：患有维生素 D 缺乏症和酒精使用障碍的成年人在补充维生素期间，qMVC 值有所改善。尽管VIDIO的25（OH）D浓度较高，但就肌肉健康而言，没有任何一种维生素策略优于另一种维生素策略的建议：试验登记：荷兰试验登记（NTR）标识符：NTR4114.

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Alcohol use disorder and muscle weakness: Original study of the effect of vitamin D supplementation in ambulatory participants with alcohol use disorder

Introduction

Chronic alcohol-related myopathy presents with proximal muscle weakness. We studied the effect of vitamin D supplementation on muscle weakness in adults with alcohol use disorder.

Method

The study was a randomized controlled trial. Participants were community-dwelling adults with alcohol use disorder. Participants allocated to VIDIO, vitamin D intensive outreach, received bimonthly oral doses of 50,000–100,000 IU cholecalciferol for 12 months. Participants allocated to CAU, care as usual, received prescriptions of once-a-day tablets containing 800 IU cholecalciferol and 500 mg calcium carbonate. Data included demographic variables, laboratory tests, alcohol use, and rating scales of help-seeking and support. Main outcomes were the participants’ quadriceps maximum voluntary contractions (qMVC) and serum-25(OH)vitamin D concentrations, 25(OH)D.

Results

In 66 participants, sex ratio 50/16, mean age 51 years, alcohol use was a median of 52 [IQR 24–95] drinks per week. Baseline qMVC values were 77% (SD 29%) of reference values. Laboratory tests were available in 44/66 participants: baseline 25(OH)D concentrations were 39.4 (SD 23.7) nmol/L. Thirty-one participants with 25(OH)D concentrations <50 nmol/L received either VIDIO or CAU and improved in qMVC, respectively, with a mean of 51 (p < 0.05) and 62 N (no p value because of loss of follow-up) after one year of treatment. Vitamin D status increased with a mean of +56.1 and + 37.4 nmol/L, respectively, in VIDIO and CAU.

Conclusion

The qMVC values improved during vitamin supplementation in adults with vitamin D deficiency and alcohol use disorder. Despite higher 25(OH)D concentrations in VIDIO, in terms of muscle health no advice could be given in favor of one vitamin strategy over the other.

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来源期刊

Alcohol 医学-毒理学

CiteScore

4.60

自引率

4.30%

发文量

审稿时长

15.6 weeks

期刊介绍： Alcohol is an international, peer-reviewed journal that is devoted to publishing multi-disciplinary biomedical research on all aspects of the actions or effects of alcohol on the nervous system or on other organ systems. Emphasis is given to studies into the causes and consequences of alcohol abuse and alcoholism, and biomedical aspects of diagnosis, etiology, treatment or prevention of alcohol-related health effects. Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and relapse. In addition, the journal reports studies on the effects alcohol on brain mechanisms of neuroplasticity over the life span, biological factors associated with adolescent alcohol abuse, pharmacotherapeutic strategies in the treatment of alcoholism, biological and biochemical markers of alcohol abuse and alcoholism, pathological effects of uncontrolled drinking, biomedical and molecular factors in the effects on liver, immune system, and other organ systems, and biomedical aspects of fetal alcohol spectrum disorder including mechanisms of damage, diagnosis and early detection, treatment, and prevention. Articles are published from all levels of biomedical inquiry, including the following: molecular and cellular studies of alcohol''s actions in vitro and in vivo; animal model studies of genetic, pharmacological, behavioral, developmental or pathophysiological aspects of alcohol; human studies of genetic, behavioral, cognitive, neuroimaging, or pathological aspects of alcohol drinking; clinical studies of diagnosis (including dual diagnosis), treatment, prevention, and epidemiology. The journal will publish 9 issues per year; the accepted abbreviation for Alcohol for bibliographic citation is Alcohol.