对受创伤影响的难民进行舍曲林与文拉法辛联合心理治疗--一项实用随机试验的后续研究。

IF 1.5 4区 医学 Q3 PSYCHIATRY
Nordic Journal of Psychiatry Pub Date : 2024-05-01 Epub Date: 2024-03-07 DOI:10.1080/08039488.2024.2324357
Maria Barhoma, Jessica Carlsson, Charlotte Sonne
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引用次数: 0

摘要

背景:针对受创伤影响的难民的长期药物治疗研究很少。这项随机试验的后续研究旨在调查舍曲林与文拉法辛联合心理疗法在试验结束后6个月和18个月的效果:主要结果是创伤后应激障碍症状,由哈佛创伤问卷(HTQ)测量。次要结果包括霍普金斯症状核对表-25(HSCL-25)、症状核对表-90(SCL)中的躯体化项目、视觉模拟量表中的疼痛、WHO-5、希恩残疾量表、汉密尔顿抑郁和焦虑量表中的幸福感以及全球功能评估。此外,还采用了简短版近期生活事件(IRLE)来了解患者在随访期间的治疗情况和生活事件:在试验期间符合意向治疗分析条件的 195 名患者中,116 人参加了 6 个月的随访,97 人参加了 18 个月的随访。意向治疗分析结果显示,在创伤后应激障碍症状的主要评估结果(HTQ)上,两组之间没有显著的长期差异。在18个月的随访中,在焦虑、抑郁和躯体化症状(HSCL-25和SCL)方面,文拉法辛对次要结果有明显优势,但仅进行了意向治疗分析,而未按协议分析:由于意向治疗分析和按协议分析的结果相互矛盾,因此无法得出结论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sertraline versus venlafaxine combined with psychotherapy in trauma-affected refugees - a follow-up study on a pragmatic randomised trial.

Background: Research on long-term pharmacotherapy for trauma-affected refugees is scarce. The purpose of this follow-up study of a randomised trial was to investigate the effects of sertraline compared to venlafaxine in combination with psychotherapy, 6 and 18 months after end of trial.

Method: The primary outcome was PTSD symptoms, measured by the Harvard Trauma Questionnaire (HTQ). The secondary outcomes included: Hopkins Symptom Checklist-25 (HSCL-25), somatisation items of the Symptoms Checklist-90 (SCL), pain on a visual analogue scale, well-being on the WHO-5, Sheehan Disability Scale, Hamilton Depression and Anxiety scales and Global Assessment of Functioning. Moreover, the shorter version of the Recent Life Events (IRLE) was adopted to obtain information regarding the patients' treatment and life events between the follow-up periods.

Results: Out of 195 patients eligible for intention-to-treat analyses during trial, 116 participated in the 6-month follow-up and 97 participated in the 18-month follow-up. The results of our intention-to-treat analyses revealed no significant long-term differences between the groups on the primary outcome assessing PTSD symptoms (HTQ). For the secondary outcomes significant differences were found at the 18-month follow-up in favour of venlafaxine assessing symptoms of anxiety, depression and somatisation (HSCL-25 and SCL), although only in intention-to-treat and not per-protocol analyses.

Conclusions: No conclusions could be drawn due to conflicting results between our intention-to-treat and per-protocol analyses.

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来源期刊
Nordic Journal of Psychiatry
Nordic Journal of Psychiatry 医学-精神病学
CiteScore
3.60
自引率
5.60%
发文量
86
审稿时长
12 months
期刊介绍: Nordic Journal of Psychiatry publishes international research on all areas of psychiatry. Nordic Journal of Psychiatry is the official journal for the eight psychiatry associations in the Nordic and Baltic countries. The journal aims to provide a leading international forum for high quality research on all themes of psychiatry including: Child psychiatry Adult psychiatry Psychotherapy Pharmacotherapy Social psychiatry Psychosomatic medicine Nordic Journal of Psychiatry accepts original research articles, review articles, brief reports, editorials and letters to the editor.
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