菲力蛋白通过减少内皮素1信号传导,改善盐敏感性高血压小鼠的心肌重塑。

IF 2.8 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Qingman Luo, Qiao Liu, Kecheng Tang, Bin Zhong, Shengqian Yang, Xiaohui Li
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引用次数: 0

摘要

目标:长期处于慢性高血压状态会使心脏过度紧张,导致心肌重塑。从天然植物连翘中提取的菲利蛋白具有保护心脏的作用。本研究旨在探讨菲利蛋白在高血压诱导的小鼠心肌重塑中的作用和机制:方法:我们构建了盐敏感性高血压小鼠模型。方法:我们构建了盐敏感性高血压小鼠模型,用不同剂量的菲力蛋白处理小鼠,并对其血压、心脏功能、心脏肥大、纤维化、炎症等情况进行评估:我们的研究结果表明,菲利林具有降低脱氧皮质酮醋酸盐高血压小鼠血压、增强心脏功能、减轻心脏肥大、纤维化和炎症反应的潜力。在高血压小鼠的心脏组织中,内皮素1(ET-1)的表达量升高,而菲林可以降低这种表达量。此外,菲利灵还能有效减少 ET-1 刺激 H9c2 细胞引起的肥大:我们的研究强调了菲利灵通过减少 ET-1 信号传导治疗心肌重塑的能力。这些结果有助于推进菲利林的新型应用,并为该领域未来的研究奠定了坚实的概念基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Phillyrin improves myocardial remodeling in salt-sensitive hypertensive mice by reducing endothelin1 signaling.

Objectives: Prolonged exposure to chronic hypertension places the heart under excessive strain, resulting in myocardial remodeling. Phillyrin, derived from the natural plant Forsythia suspensa, has been found to possess cardioprotective properties. The objective of this study is to investigate the role and mechanism of phillyrin in hypertension-induced myocardial remodeling in mice.

Methods: We constructed a mouse model of salt-sensitive hypertension. The mice were treated with varying doses of phillyrin, and their blood pressure, cardiac function, cardiac hypertrophy, fibrosis, inflammation, and other conditions were assessed.

Key findings: Our research findings demonstrated that phillyrin has the potential to lower blood pressure, enhance cardiac function, and mitigate cardiac hypertrophy, fibrosis, and inflammatory responses in deoxycorticosterone acetate-salt hypertension mice. In hypertensive mice, there was an elevated expression of endothelin1 (ET-1) in heart tissue, which can be reduced by phillyrin. Additionally, phillyrin effectively reduced the hypertrophy of H9c2 cells induced by ET-1 stimulation.

Conclusions: Our research highlights the therapeutic capabilities of phillyrin in the treatment of myocardial remodeling through the reduction of ET-1 signaling. These results contribute to the advancement of novel applications for phillyrin and establish a solid conceptual basis for future investigations in this area.

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来源期刊
CiteScore
6.60
自引率
0.00%
发文量
91
审稿时长
3 months
期刊介绍: JPP keeps pace with new research on how drug action may be optimized by new technologies, and attention is given to understanding and improving drug interactions in the body. At the same time, the journal maintains its established and well-respected core strengths in areas such as pharmaceutics and drug delivery, experimental and clinical pharmacology, biopharmaceutics and drug disposition, and drugs from natural sources. JPP publishes at least one special issue on a topical theme each year.
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