基于干细胞的帕金森病研究方法。

IF 2.5 4区医学 Q3 CELL & TISSUE ENGINEERING

International journal of stem cells Pub Date : 2024-03-07 DOI:10.15283/ijsc23169

Min Seong Kim, Subeen Yoon, Jiwoo Choi, Yong Jun Kim, Gabsang Lee

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引用次数: 0

摘要

帕金森病（PD）是一种神经退行性疾病，其特征是中脑多巴胺能神经元的丧失，从而导致运动症状。虽然目前的治疗方法能提供有限的缓解，但无法改变疾病的进展。干细胞技术涉及患者特异性干细胞衍生神经元，为研究和个性化再生疗法提供了一条前景广阔的途径。本文回顾了基于干细胞的帕金森病研究潜力，总结了正在进行的工作及其局限性，并介绍了创新研究模型。干细胞技术与先进模型的结合有望增强我们对帕金森病的理解和治疗策略。

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Stem Cell-Based Approaches in Parkinson's Disease Research.

Parkinson's disease (PD) is a neurodegenerative condition characterized by the loss of midbrain dopaminergic neurons, leading to motor symptoms. While current treatments provide limited relief, they don't alter disease progression. Stem cell technology, involving patient-specific stem cell-derived neurons, offers a promising avenue for research and personalized regenerative therapies. This article reviews the potential of stem cell-based research in PD, summarizing ongoing efforts, their limitations, and introducing innovative research models. The integration of stem cell technology and advanced models promises to enhance our understanding and treatment strategies for PD.

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来源期刊

International journal of stem cells Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

5.10

自引率

4.30%

发文量

期刊介绍： International Journal of Stem Cells (Int J Stem Cells), a peer-reviewed open access journal, principally aims to provide a forum for investigators in the field of stem cell biology to present their research findings and share their visions and opinions. Int J Stem Cells covers all aspects of stem cell biology including basic, clinical and translational research on genetics, biochemistry, and physiology of various types of stem cells including embryonic, adult and induced stem cells. Reports on epigenetics, genomics, proteomics, metabolomics of stem cells are welcome as well. Int J Stem Cells also publishes review articles, technical reports and treatise on ethical issues.