促进巴西的生命科学研究:建立当地果蝇种群中心。

IF 1.7 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Genetics and Molecular Biology Pub Date : 2024-02-19 eCollection Date: 2024-01-01 DOI:10.1590/1678-4685-GMB-2023-0202
Marcos T Oliveira, Lucas Anhezini, Helena M Araujo, Marcus F Oliveira, Carlos A Couto-Lima
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引用次数: 0

摘要

黑腹果蝇无疑是生物学中最有用的模式生物之一。它最初被用于巩固遗传学原理、建立群体遗传学和进化合成理论的基本概念,而现在它能为科学家提供更多的东西:研究从免疫系统的发育和功能到动物神经发生、肿瘤发生等大量细胞和生物机制的可能性。全世界的果蝇研究人员都可以获得广泛的资源,包括目前由北美、欧洲和亚洲的基因库中心提供的越来越多的突变株、转基因株和基因组编辑株。在这里,我们提供了证据,证明近几十年来种群中心在维持全球果蝇研究成果大幅增长方面的重要性。我们还讨论了巴西果蝇科学家在保持其研究项目的国际竞争力方面所面临的挑战,并认为从国际种群中心进口果蝇品系的困难极大地阻碍了巴西所有果蝇研究领域的发展。建立本地种群中心可能是建立强大的本地果蝇群体的第一步,这将为生命科学研究的所有领域做出贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Boosting life sciences research in Brazil: building a case for a local Drosophila stock center.

Drosophila melanogaster is undoubtedly one of the most useful model organisms in biology. Initially used in solidifying the principles of heredity, and establishing the basic concepts of population genetics and of the synthetic theory of evolution, it can currently offer scientists much more: the possibility of investigating a plethora of cellular and biological mechanisms, from development and function of the immune system to animal neurogenesis, tumorigenesis and beyond. Extensive resources are available for the community of Drosophila researchers worldwide, including an ever-growing number of mutant, transgenic and genomically-edited lines currently carried by stock centers in North America, Europe and Asia. Here, we provide evidence for the importance of stock centers in sustaining the substantial increase in the output of Drosophila research worldwide in recent decades. We also discuss the challenges that Brazilian Drosophila scientists face to keep their research projects internationally competitive, and argue that difficulties in importing fly lines from international stock centers have significantly stalled the progression of all Drosophila research areas in the country. Establishing a local stock center might be the first step towards building a strong local Drosophila community that will likely contribute to all areas of life sciences research.

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来源期刊
Genetics and Molecular Biology
Genetics and Molecular Biology 生物-生化与分子生物学
CiteScore
4.20
自引率
4.80%
发文量
111
审稿时长
3 months
期刊介绍: Genetics and Molecular Biology (formerly named Revista Brasileira de Genética/Brazilian Journal of Genetics - ISSN 0100-8455) is published by the Sociedade Brasileira de Genética (Brazilian Society of Genetics). The Journal considers contributions that present the results of original research in genetics, evolution and related scientific disciplines. Manuscripts presenting methods and applications only, without an analysis of genetic data, will not be considered.
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