Marlon D. Joseph, Martha R. Koenig, Andrea S. Kuriyama, Tanran R. Wang, Amelia K. Wesselink, Michael L. Eisenberg, Greg J. Sommer, Kenneth J. Rothman, Sherri O. Stuver, Lauren A. Wise, Elizabeth E. Hatch
{"title":"一项关于含糖饮料消费与精液质量的孕前队列研究。","authors":"Marlon D. Joseph, Martha R. Koenig, Andrea S. Kuriyama, Tanran R. Wang, Amelia K. Wesselink, Michael L. Eisenberg, Greg J. Sommer, Kenneth J. Rothman, Sherri O. Stuver, Lauren A. Wise, Elizabeth E. Hatch","doi":"10.1111/andr.13615","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Dietary factors, including high sugar intake, may have adverse effects on male reproduction. Studies of the association between sugar-sweetened beverage (SSB) intake and semen quality have reported inconsistent results.</p>\n </section>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>We estimated the effects of SSB consumption on semen quality in a North American preconception cohort study.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We analyzed baseline data from 690 males (<i>n</i> = 1,247 samples) participating in Pregnancy Study Online (PRESTO) during 2015–2022. Participants aged ≥21 years completed a baseline questionnaire on which they reported information about intake of SSBs, including sodas, energy drinks, sports drinks, and fruit juices. After enrollment, we invited U.S. participants to a semen testing substudy, in which they collected and analyzed two samples using an at-home semen testing kit. We used linear regression models to estimate adjusted percent differences (%<i>D</i>) and 95% confidence intervals (CI) for associations of SSB intake with semen volume, sperm concentration, total sperm count (TSC), motility, and total motile sperm count (TMSC). We used modified Poisson regression models to estimate adjusted risk ratios (RRs) and 95% CIs for the association of SSB intake with World Health Organization semen parameter cut points.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Relative to non-consumers of SSBs, those who consumed ≥7 SSBs/week had lower semen volume (%<i>D</i> = −6, 95% CI: −13, 0), sperm concentration (%<i>D</i> = −22, 95% CI: −38, 0), TSC (%<i>D</i> = −22, 95% CI: −38, −2), motility (%<i>D</i> = −4, 95% CI: −10, 2), and TMSC (%<i>D</i> = −25, 95% CI: −43, −2). High SSB consumers also had greater risks of low sperm concentration (≤16 million/mL; RR = 1.89, 95% CI: 1.11, 3.21), low TSC (≤39 million; RR = 1.75, 95% CI: 0.92, 3.33), low motility (≤42%; RR = 1.23, 95% CI: 0.87, 1.75) and low TMSC (≤21 million; RR = 1.95, 95% CI: 1.12, 3.38). Associations were stronger among participants with body mass index ≥ 25 kg/m<sup>2</sup>.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Greater SSB consumption was associated with reduced semen quality in a North American preconception cohort.</p>\n </section>\n </div>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":"12 8","pages":"1730-1739"},"PeriodicalIF":3.2000,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A preconception cohort study of sugar-sweetened beverage consumption and semen quality\",\"authors\":\"Marlon D. Joseph, Martha R. Koenig, Andrea S. Kuriyama, Tanran R. Wang, Amelia K. Wesselink, Michael L. Eisenberg, Greg J. Sommer, Kenneth J. Rothman, Sherri O. Stuver, Lauren A. Wise, Elizabeth E. Hatch\",\"doi\":\"10.1111/andr.13615\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Dietary factors, including high sugar intake, may have adverse effects on male reproduction. Studies of the association between sugar-sweetened beverage (SSB) intake and semen quality have reported inconsistent results.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>We estimated the effects of SSB consumption on semen quality in a North American preconception cohort study.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>We analyzed baseline data from 690 males (<i>n</i> = 1,247 samples) participating in Pregnancy Study Online (PRESTO) during 2015–2022. Participants aged ≥21 years completed a baseline questionnaire on which they reported information about intake of SSBs, including sodas, energy drinks, sports drinks, and fruit juices. After enrollment, we invited U.S. participants to a semen testing substudy, in which they collected and analyzed two samples using an at-home semen testing kit. We used linear regression models to estimate adjusted percent differences (%<i>D</i>) and 95% confidence intervals (CI) for associations of SSB intake with semen volume, sperm concentration, total sperm count (TSC), motility, and total motile sperm count (TMSC). We used modified Poisson regression models to estimate adjusted risk ratios (RRs) and 95% CIs for the association of SSB intake with World Health Organization semen parameter cut points.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Relative to non-consumers of SSBs, those who consumed ≥7 SSBs/week had lower semen volume (%<i>D</i> = −6, 95% CI: −13, 0), sperm concentration (%<i>D</i> = −22, 95% CI: −38, 0), TSC (%<i>D</i> = −22, 95% CI: −38, −2), motility (%<i>D</i> = −4, 95% CI: −10, 2), and TMSC (%<i>D</i> = −25, 95% CI: −43, −2). High SSB consumers also had greater risks of low sperm concentration (≤16 million/mL; RR = 1.89, 95% CI: 1.11, 3.21), low TSC (≤39 million; RR = 1.75, 95% CI: 0.92, 3.33), low motility (≤42%; RR = 1.23, 95% CI: 0.87, 1.75) and low TMSC (≤21 million; RR = 1.95, 95% CI: 1.12, 3.38). Associations were stronger among participants with body mass index ≥ 25 kg/m<sup>2</sup>.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Greater SSB consumption was associated with reduced semen quality in a North American preconception cohort.</p>\\n </section>\\n </div>\",\"PeriodicalId\":7898,\"journal\":{\"name\":\"Andrology\",\"volume\":\"12 8\",\"pages\":\"1730-1739\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-03-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Andrology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/andr.13615\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ANDROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Andrology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/andr.13615","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ANDROLOGY","Score":null,"Total":0}
A preconception cohort study of sugar-sweetened beverage consumption and semen quality
Background
Dietary factors, including high sugar intake, may have adverse effects on male reproduction. Studies of the association between sugar-sweetened beverage (SSB) intake and semen quality have reported inconsistent results.
Objective
We estimated the effects of SSB consumption on semen quality in a North American preconception cohort study.
Methods
We analyzed baseline data from 690 males (n = 1,247 samples) participating in Pregnancy Study Online (PRESTO) during 2015–2022. Participants aged ≥21 years completed a baseline questionnaire on which they reported information about intake of SSBs, including sodas, energy drinks, sports drinks, and fruit juices. After enrollment, we invited U.S. participants to a semen testing substudy, in which they collected and analyzed two samples using an at-home semen testing kit. We used linear regression models to estimate adjusted percent differences (%D) and 95% confidence intervals (CI) for associations of SSB intake with semen volume, sperm concentration, total sperm count (TSC), motility, and total motile sperm count (TMSC). We used modified Poisson regression models to estimate adjusted risk ratios (RRs) and 95% CIs for the association of SSB intake with World Health Organization semen parameter cut points.
Results
Relative to non-consumers of SSBs, those who consumed ≥7 SSBs/week had lower semen volume (%D = −6, 95% CI: −13, 0), sperm concentration (%D = −22, 95% CI: −38, 0), TSC (%D = −22, 95% CI: −38, −2), motility (%D = −4, 95% CI: −10, 2), and TMSC (%D = −25, 95% CI: −43, −2). High SSB consumers also had greater risks of low sperm concentration (≤16 million/mL; RR = 1.89, 95% CI: 1.11, 3.21), low TSC (≤39 million; RR = 1.75, 95% CI: 0.92, 3.33), low motility (≤42%; RR = 1.23, 95% CI: 0.87, 1.75) and low TMSC (≤21 million; RR = 1.95, 95% CI: 1.12, 3.38). Associations were stronger among participants with body mass index ≥ 25 kg/m2.
Conclusion
Greater SSB consumption was associated with reduced semen quality in a North American preconception cohort.
期刊介绍：
Andrology is the study of the male reproductive system and other male gender related health issues. Andrology deals with basic and clinical aspects of the male reproductive system (gonads, endocrine and accessory organs) in all species, including the diagnosis and treatment of medical problems associated with sexual development, infertility, sexual dysfunction, sex hormone action and other urological problems. In medicine, Andrology as a specialty is a recent development, as it had previously been considered a subspecialty of urology or endocrinology
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