了解儿童脂质转移蛋白致敏模式及其临床意义。

IF 2.6 3区 医学 Q2 ALLERGY
Alp Kazancioglu, Ilteber Konuralp, Umit Murat Sahiner, Ozge Soyer, Bulent Enis Sekerel
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引用次数: 0

摘要

背景:脂质转移蛋白(LTP)是地中海地区最常见的食物过敏原。研究目的本研究旨在调查 LTP 过敏原分子在广泛的过敏原特异性致敏模式中的共敏模式和群集关系,以及地中海东部儿童的临床结果。研究方法在 496 名接受多重测试评估的多重致敏儿童中,对 105 名(21%)具有 16 种不同 LTP 致敏模式的儿童进行了分析。根据免疫球蛋白 E 介导症状(口腔过敏综合征 [OAS]、全身反应和过敏性休克)的明确病史对临床反应性进行了检查。结果:所有被纳入研究的儿童都对食物LTPs敏感,但56%的儿童对花粉LTPs敏感。对 OAS 和临床反应敏感的儿童人数分别为 12 人和 59 人,未报告任何辅助因素。最常见的致敏因子是 Pru p 3(74%)和 Cor a 8(66%)。除 Par j 2 和 Tri a 14 外,在热图中还观察到 LTP 分子之间存在明显的相关性。总体而言,临床反应性与年龄和 LTP 分子阳性数量的增加有关。结论在地中海东部地区,21%的对多种食物和/或花粉过敏的儿童被发现对 LTP 过敏;然而,几乎一半的儿童报告了临床反应性。分层路径突出表明,不同的 LTP 过敏原分子可作为主要致敏原。临床反应性与 LTP 分子阳性数量的增加和年龄的增长有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Understanding of lipid transfer protein sensitization patterns and its clinical significance in children.

Background: Lipid transfer proteins (LTP) are the most common food allergens in the Mediterranean region. Objective: The study aimed to investigate co-sensitization patterns and cluster relationships between LTP allergen molecules across a broad range of allergen-specific sensitization patterns, and clinical outcomes in eastern Mediterranean children. Methods: Among 496 children evaluated for multiple sensitizations with multiplex testing, 105 children (21%) with 16 different LTP sensitizations were analyzed. Clinical reactivity was examined based on clear-cut history of immunoglobulin E mediated symptoms (oral allergy syndrome [OAS], systemic reactions, and anaphylaxis). Results: All children included were sensitive to food LTPs, but 56% were sensitive to pollen LTPs. The number of children with OAS and clinical reactivity was 12 and 59, respectively, and no cofactors were reported. The most common sensitizations were Pru p 3 (74%) and Cor a 8 (66%). Significant correlations were observed in the heatmap between the LTP molecules other than Par j 2 and Tri a 14. Overall, clinical reactivity was associated with increased age and number of LTP molecule positivity. Conclusion: In the eastern Mediterranean region, 21% of children with multiple food and/or pollen sensitizations were found to have LTP sensitization; however, almost half reported clinical reactivity. The hierarchical pathway highlights that distinct LTP allergen molecules can act as primary sensitizers. Clinical reactivity is linked to increasing numbers of LTP molecule positivity and increasing age.

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来源期刊
CiteScore
5.70
自引率
35.70%
发文量
106
审稿时长
6-12 weeks
期刊介绍: Allergy & Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists. The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma. Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.
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