Mădălina Iuliana Mușat, Smaranda Ioana Mitran, Ion Udriștoiu, Carmen Valeria Albu, Bogdan Cătălin
{"title":"压力对肝损伤 C57BL/6 小鼠行为的影响：一项比较研究","authors":"Mădălina Iuliana Mușat, Smaranda Ioana Mitran, Ion Udriștoiu, Carmen Valeria Albu, Bogdan Cătălin","doi":"10.3389/fnbeh.2024.1358964","DOIUrl":null,"url":null,"abstract":"<sec><title>Introduction</title><p>Depressive-like behavior has been shown to be associated with liver damage. This study aimed to evaluate the impact of three different models of depression on the behavior of mice with liver injury.</p></sec><sec><title>Methods</title><p>During the 4 weeks of methionine/choline deficiency diet (MCD), adult C57BL/6 mice were randomly divided into four groups: MCD (no stress protocol, <italic>n</italic> = 6), chronic unpredictable mild stress (CUMS, <italic>n</italic> = 9), acute and repeated forced swim stress [aFSS (<italic>n</italic> = 9) and rFSS (<italic>n</italic> = 9)].</p></sec><sec><title>Results</title><p>All depression protocols induced increased anhedonia and anxiety-like behavior compared to baseline and had no impact on the severity of liver damage, according to ultrasonography. However, different protocols evoked different overall behavior patterns. After the depressive-like behavior induction protocols, animals subjected to aFSS did not exhibit anxiety-like behavior differences compared to MCD animals, while mice subjected to CUMS showed additional weight loss compared to FSS animals. All tested protocols for inducing depressive-like behavior decreased the short-term memory of mice with liver damage, as assessed by the novel object recognition test (NORT).</p></sec><sec><title>Discussion</title><p>Our results show that the use of all protocols seems to generate different levels of anxiety-like behavior, but only the depressive-like behavior induction procedures associate additional anhedonia and memory impairment in mice with liver injury.</p></sec>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The impact of stress on the behavior of C57BL/6 mice with liver injury: a comparative study\",\"authors\":\"Mădălina Iuliana Mușat, Smaranda Ioana Mitran, Ion Udriștoiu, Carmen Valeria Albu, Bogdan Cătălin\",\"doi\":\"10.3389/fnbeh.2024.1358964\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<sec><title>Introduction</title><p>Depressive-like behavior has been shown to be associated with liver damage. 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The impact of stress on the behavior of C57BL/6 mice with liver injury: a comparative study
Introduction
Depressive-like behavior has been shown to be associated with liver damage. This study aimed to evaluate the impact of three different models of depression on the behavior of mice with liver injury.
Methods
During the 4 weeks of methionine/choline deficiency diet (MCD), adult C57BL/6 mice were randomly divided into four groups: MCD (no stress protocol, n = 6), chronic unpredictable mild stress (CUMS, n = 9), acute and repeated forced swim stress [aFSS (n = 9) and rFSS (n = 9)].
Results
All depression protocols induced increased anhedonia and anxiety-like behavior compared to baseline and had no impact on the severity of liver damage, according to ultrasonography. However, different protocols evoked different overall behavior patterns. After the depressive-like behavior induction protocols, animals subjected to aFSS did not exhibit anxiety-like behavior differences compared to MCD animals, while mice subjected to CUMS showed additional weight loss compared to FSS animals. All tested protocols for inducing depressive-like behavior decreased the short-term memory of mice with liver damage, as assessed by the novel object recognition test (NORT).
Discussion
Our results show that the use of all protocols seems to generate different levels of anxiety-like behavior, but only the depressive-like behavior induction procedures associate additional anhedonia and memory impairment in mice with liver injury.
期刊介绍：
Frontiers in Behavioral Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the neural mechanisms underlying behavior. Field Chief Editor Nuno Sousa at the Instituto de Pesquisa em Ciências da Vida e da Saúde (ICVS) is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
This journal publishes major insights into the neural mechanisms of animal and human behavior, and welcomes articles studying the interplay between behavior and its neurobiological basis at all levels: from molecular biology and genetics, to morphological, biochemical, neurochemical, electrophysiological, neuroendocrine, pharmacological, and neuroimaging studies.
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