普通人群中 V122I TTR 中年携带者的循环转甲状腺素和视黄醇结合蛋白 4 水平。

IF 5.2 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Nicholas S Hendren, James A De Lemos, Jarett D Berry, Julia Kozlitina, Lorena Saelices, Alan X Ji, Zhili Shao, Chia-Feng Liu, Sonia Garg, Maryjane A Farr, Mark H Drazner, W H Wilson Tang, Justin L Grodin
{"title":"普通人群中 V122I TTR 中年携带者的循环转甲状腺素和视黄醇结合蛋白 4 水平。","authors":"Nicholas S Hendren, James A De Lemos, Jarett D Berry, Julia Kozlitina, Lorena Saelices, Alan X Ji, Zhili Shao, Chia-Feng Liu, Sonia Garg, Maryjane A Farr, Mark H Drazner, W H Wilson Tang, Justin L Grodin","doi":"10.1080/13506129.2024.2322479","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Hereditary transthyretin cardiac amyloidosis (ATTRv-CA) has a long latency phase before clinical onset, creating a need to identify subclinical disease. We hypothesized circulating transthyretin (TTR) and retinol binding protein 4 (RBP4) levels would be associated with <i>TTR</i> carrier status and correlated with possible evidence of subclinical ATTRv-CA.</p><p><strong>Methods: </strong>TTR and RBP4 were measured in blood samples from V122I <i>TTR</i> carriers and age-, sex- and race-matched non-carrier controls (1:2 matching) among Dallas Heart Study participants (phases 1 (DHS-1) and 2 (DHS-2)). Multivariable linear regression models determined factors associated with TTR and RBP4.</p><p><strong>Results: </strong>There were 40 V122I <i>TTR</i> carriers in DHS-1 and 54 V122I <i>TTR</i> carriers in DHS-2. In DHS-1 and DHS-2, TTR was lower in V122I <i>TTR</i> carriers (<i>p</i> < .001 for both), and RBP4 in DHS-2 was lower in V122I <i>TTR</i> carriers than non-carriers (<i>p</i> = .002). Among V122I <i>TTR</i> carriers, TTR was negatively correlated with markers of kidney function, and limb lead voltage (<i>p</i> < .05 for both) and TTR and RBP4 were correlated with atrial volume in DHS-2 (<i>p</i> < .05).</p><p><strong>Conclusions: </strong>V122I TTR carrier status is independently associated with lower TTR and RBP4 in comparison with non-carriers. These findings support the hypothesis that TTR and RBP4 may correlate with evidence of subclinical ATTRv-CA.</p>","PeriodicalId":50964,"journal":{"name":"Amyloid-Journal of Protein Folding Disorders","volume":null,"pages":null},"PeriodicalIF":5.2000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11127723/pdf/","citationCount":"0","resultStr":"{\"title\":\"Circulating transthyretin and retinol binding protein 4 levels among middle-age V122I <i>TTR</i> carriers in the general population.\",\"authors\":\"Nicholas S Hendren, James A De Lemos, Jarett D Berry, Julia Kozlitina, Lorena Saelices, Alan X Ji, Zhili Shao, Chia-Feng Liu, Sonia Garg, Maryjane A Farr, Mark H Drazner, W H Wilson Tang, Justin L Grodin\",\"doi\":\"10.1080/13506129.2024.2322479\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Hereditary transthyretin cardiac amyloidosis (ATTRv-CA) has a long latency phase before clinical onset, creating a need to identify subclinical disease. We hypothesized circulating transthyretin (TTR) and retinol binding protein 4 (RBP4) levels would be associated with <i>TTR</i> carrier status and correlated with possible evidence of subclinical ATTRv-CA.</p><p><strong>Methods: </strong>TTR and RBP4 were measured in blood samples from V122I <i>TTR</i> carriers and age-, sex- and race-matched non-carrier controls (1:2 matching) among Dallas Heart Study participants (phases 1 (DHS-1) and 2 (DHS-2)). Multivariable linear regression models determined factors associated with TTR and RBP4.</p><p><strong>Results: </strong>There were 40 V122I <i>TTR</i> carriers in DHS-1 and 54 V122I <i>TTR</i> carriers in DHS-2. In DHS-1 and DHS-2, TTR was lower in V122I <i>TTR</i> carriers (<i>p</i> < .001 for both), and RBP4 in DHS-2 was lower in V122I <i>TTR</i> carriers than non-carriers (<i>p</i> = .002). Among V122I <i>TTR</i> carriers, TTR was negatively correlated with markers of kidney function, and limb lead voltage (<i>p</i> < .05 for both) and TTR and RBP4 were correlated with atrial volume in DHS-2 (<i>p</i> < .05).</p><p><strong>Conclusions: </strong>V122I TTR carrier status is independently associated with lower TTR and RBP4 in comparison with non-carriers. These findings support the hypothesis that TTR and RBP4 may correlate with evidence of subclinical ATTRv-CA.</p>\",\"PeriodicalId\":50964,\"journal\":{\"name\":\"Amyloid-Journal of Protein Folding Disorders\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.2000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11127723/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Amyloid-Journal of Protein Folding Disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/13506129.2024.2322479\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/3/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Amyloid-Journal of Protein Folding Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/13506129.2024.2322479","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/6 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:遗传性转甲状腺素心脏淀粉样变性(ATTRv-CA)在临床发病前有很长的潜伏期,因此需要识别亚临床疾病。我们假设循环中的转甲状腺素(TTR)和视黄醇结合蛋白 4(RBP4)水平与 TTR 携带者状态有关,并与亚临床 ATTRv-CA 的可能证据相关:在达拉斯心脏研究参与者(第一阶段(DHS-1)和第二阶段(DHS-2))中,对 V122I TTR 携带者和年龄、性别及种族匹配的非携带者对照组(1:2 匹配)的血液样本中的 TTR 和 RBP4 进行了测量。多变量线性回归模型确定了与 TTR 和 RBP4 相关的因素:结果:DHS-1 中有 40 名 V122I TTR 携带者,DHS-2 中有 54 名 V122I TTR 携带者。在 DHS-1 和 DHS-2 中,V122I TTR 携带者(p TTR 携带者)的 TTR 低于非携带者(p = .002)。在 V122I TTR 携带者中,TTR 与肾功能指标和肢体导联电压呈负相关(p p 结论):与非携带者相比,V122I TTR 携带者身份与较低的 TTR 和 RBP4 独立相关。这些发现支持 TTR 和 RBP4 可能与亚临床 ATTRv-CA 的证据相关的假设。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Circulating transthyretin and retinol binding protein 4 levels among middle-age V122I TTR carriers in the general population.

Background: Hereditary transthyretin cardiac amyloidosis (ATTRv-CA) has a long latency phase before clinical onset, creating a need to identify subclinical disease. We hypothesized circulating transthyretin (TTR) and retinol binding protein 4 (RBP4) levels would be associated with TTR carrier status and correlated with possible evidence of subclinical ATTRv-CA.

Methods: TTR and RBP4 were measured in blood samples from V122I TTR carriers and age-, sex- and race-matched non-carrier controls (1:2 matching) among Dallas Heart Study participants (phases 1 (DHS-1) and 2 (DHS-2)). Multivariable linear regression models determined factors associated with TTR and RBP4.

Results: There were 40 V122I TTR carriers in DHS-1 and 54 V122I TTR carriers in DHS-2. In DHS-1 and DHS-2, TTR was lower in V122I TTR carriers (p < .001 for both), and RBP4 in DHS-2 was lower in V122I TTR carriers than non-carriers (p = .002). Among V122I TTR carriers, TTR was negatively correlated with markers of kidney function, and limb lead voltage (p < .05 for both) and TTR and RBP4 were correlated with atrial volume in DHS-2 (p < .05).

Conclusions: V122I TTR carrier status is independently associated with lower TTR and RBP4 in comparison with non-carriers. These findings support the hypothesis that TTR and RBP4 may correlate with evidence of subclinical ATTRv-CA.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Amyloid-Journal of Protein Folding Disorders
Amyloid-Journal of Protein Folding Disorders 生物-生化与分子生物学
CiteScore
10.60
自引率
10.90%
发文量
48
审稿时长
6-12 weeks
期刊介绍: Amyloid: the Journal of Protein Folding Disorders is dedicated to the study of all aspects of the protein groups and associated disorders that are classified as the amyloidoses as well as other disorders associated with abnormal protein folding. The journals major focus points are: etiology, pathogenesis, histopathology, chemical structure, nature of fibrillogenesis; whilst also publishing papers on the basic and chemical genetic aspects of many of these disorders. Amyloid is recognised as one of the leading publications on amyloid protein classifications and the associated disorders, as well as clinical studies on all aspects of amyloid related neurodegenerative diseases and major clinical studies on inherited amyloidosis, especially those related to transthyretin. The Journal also publishes book reviews, meeting reports, editorials, thesis abstracts, review articles and symposia in the various areas listed above.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信