Chun Hou Huang, Bee Song Chang, Tai-Chu Peng, Yun-Hsin Peng
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Inflammatory and Nutritional Biomarkers in Patients With Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemotherapy and Radiation Therapy.
Objectives: To investigate the relationship between pretreatment inflammatory and nutritional biomarkers in patients with esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant chemotherapy and radiation therapy (nCRT).
Sample & setting: 213 patients with newly diagnosed stage II-III ESCC who received nCRT at an academic hospital in Taiwan.
Methods & variables: Electronic health record data were used. Records on inflammatory and nutritional biomarkers and clinical outcomes were extracted. Logistic regression analysis was used to predict treatment-related adverse events, Cox regression was used for survival outcomes, and receiver operating characteristic curve analysis was used to determine optimal cutoff values.
Results: There was a significant association between low prognostic nutritional index (PNI) and nCRT toxicities and survival. Advanced cancer stage, high platelet-to-lymphocyte ratio, and occurrence of pneumonia/infection were linked to survival outcomes.
Implications for nursing: PNI shows promise in predicting prognosis, helps identify high-risk patients, and enables nurses to apply tailored interventions.
期刊介绍：
The mission of the Oncology Nursing Forum, an official publication of ONS, is to
Convey research information related to practice, technology, education, and leadership.
Disseminate oncology nursing research and evidence-based practice to enhance transdisciplinary quality cancer care.
Stimulate discussion of critical issues relevant to oncology nursing.
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