电针可减轻癌痛小鼠模型的痛觉行为

IF 2.8 3区 医学 Q2 NEUROSCIENCES
Yu-Xue Zhao, Ming-Jiang Yao, Jian-Wu Shen, Wen-Xi Zhang, Yuan-Xi Zhou
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引用次数: 0

摘要

背景:疼痛是癌症患者的主要症状,而癌症诱发的骨痛(CIBP)是最常见的中度和重度癌症相关疼痛类型。目前治疗 CIBP 的镇痛疗法存在不良反应,且治疗效果有限。针灸作为一种安全的替代疗法,在疼痛治疗中被证明是有效的。我们对针灸治疗癌痛的镇痛效果进行了评估,并试图探索其潜在的镇痛机制:裸鼠左股骨远端接种癌细胞,建立癌痛模型。方法:将癌细胞接种到裸鼠的左股骨远端,建立癌痛模型。结果显示,电针治疗减轻了小鼠的癌痛行为,同时检测了小鼠外周和中枢的神经肽相关指标和炎症相关指标:结果:EA治疗缓解了癌症诱导的疼痛行为,包括机械异感、热痛和自发痛,还下调了异种移植小鼠受累足底皮肤中神经肽CGRP和p75的免疫荧光表达,抑制了异种移植小鼠腰脊髓中神经肽相关蛋白和炎症相关蛋白的过度表达:总之,我们的研究结果表明,EA治疗可改善癌痛小鼠异种移植模型中癌症诱发的疼痛行为,这可能是通过抑制肿瘤细胞异种移植后中枢水平的神经肽相关蛋白和炎症相关蛋白的表达实现的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Electroacupuncture attenuates nociceptive behaviors in a mouse model of cancer pain.

Pain is a major symptom in cancer patients, and cancer-induced bone pain (CIBP) is the most common type of moderate and severe cancer-related pain. The current available analgesic treatments for CIBP have adverse effects as well as limited therapeutic effects. Acupuncture is proved effective in pain management as a safe alternative therapy. We evaluated the analgesic effect of acupuncture in treatment of cancer pain and try to explore the underlying analgesic mechanisms. Nude mice were inoculated with cancer cells into the left distal femur to establish cancer pain model. Electroacupuncture (EA) treatment was applied for the xenograft animals. Pain behaviors of mice were evaluated, followed by the detections of neuropeptide-related and inflammation-related indicators in peripheral and central levels. EA treatment alleviated cancer-induced pain behaviors covering mechanical allodynia, thermal hyperalgesia and spontaneous pain, and also down-regulated immunofluorescence expressions of neuropeptide CGRP and p75 in the skin of affected plantar area in xenograft mice, and inhibited expressions of overexpressed neuropeptide-related and inflammation-related protein in the lumbar spinal cord of xenograft mice. Overall, our findings suggest that EA treatment ameliorated cancer-induced pain behaviors in the mouse xenograft model of cancer pain, possibly through inhibiting the expressions of neuropeptide-related and inflammation-related protein in central level following tumor cell xenografts.

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来源期刊
Molecular Pain
Molecular Pain 医学-神经科学
CiteScore
5.60
自引率
3.00%
发文量
56
审稿时长
6-12 weeks
期刊介绍: Molecular Pain is a peer-reviewed, open access journal that considers manuscripts in pain research at the cellular, subcellular and molecular levels. Molecular Pain provides a forum for molecular pain scientists to communicate their research findings in a targeted manner to others in this important and growing field.
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