邻里贫困与卵巢储备功能的关系:卵巢衰老研究。

IF 2.8 3区 医学 Q1 OBSTETRICS & GYNECOLOGY
Anwesha Pan, Kyle D Crowder, Marcelle I Cedars, Maria E Bleil
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引用次数: 0

摘要

研究目的本研究旨在探讨邻里贫困与卵巢储备功能之间的关系:在 "卵巢衰老研究"(Ovarian Aging Study)的 1,019 名绝经前健康妇女中,研究人员考察了邻里贫困与卵巢储备的生物标志物--抗苗勒氏管激素(AMH)和前卵泡计数(AFC)--之间的总体关系。具体而言,该研究对年龄-x-邻里贫困的交互作用进行了横截面评估,以确定在邻里贫困程度较高的妇女中,AMH 和 AFC 的下降幅度是否更大。通过对妇女成年后的居住地址进行地理编码并将其与美国人口普查数据联系起来,对邻里贫困状况进行了评估:独立于共变量,一个显著的交互项显示,年龄与 AMH 之间的关系因成年后暴露于邻里贫困的程度而异(b = -0.001,P < 0.05)。在低度、中度和高度社区贫困的妇女中,AMH 的下降幅度逐渐增大。此外,主效应显示,邻里贫困程度越高,只有年轻女性的 AMH 越高(b = 0.022,P < 0.01)。与 AFC 相关的结果均不显著(P > 0.05):结论:在所有女性中,成年后更多地接触邻里贫困与卵巢储备功能(以AMH为指标)降低有关。此外,在年轻女性中,邻里贫困与 AMH 之间存在正相关,而在年长女性中,这种关系有所减弱。总之,研究结果表明,邻里关系不利可能会产生不利影响,表现为最初的AMH较高,随着时间的推移,卵巢卵泡的损失会更大。不过,目前还不清楚,如果对因邻里贫困而导致的 AMH 下降进行纵向研究,这些研究女性间差异的结果是否会重现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between neighborhood poverty and ovarian reserve: the ovarian aging study.

Objective: This study aimed to examine the association between neighborhood poverty and ovarian reserve.

Methods: Among 1,019 healthy premenopausal women in the Ovarian Aging Study, aggregate exposure to neighborhood poverty was examined in relation to biomarkers of ovarian reserve, antimüllerian hormone (AMH) and antral follicle count (AFC). Specifically, the interaction of age-x-neighborhood poverty was assessed cross-sectionally to determine whether AMH and AFC declines across women may be greater in women exposed to more neighborhood poverty. Neighborhood poverty was assessed by geocoding and linking women's residential addresses in adulthood to US Census data.

Results: Independent of covariates, a significant interaction term showed the association between age and AMH varied by degree of exposure to neighborhood poverty in adulthood ( b = -0.001, P < 0.05). AMH declines increased progressively across women exposed to low, medium, and high levels of neighborhood poverty. In addition, main effects showed that higher neighborhood poverty was related to higher AMH in the younger women only ( b = 0.022, P < 0.01). Results related to AFC were all nonsignificant ( P > 0.05).

Conclusions: Across women, greater aggregate exposure to neighborhood poverty in adulthood was related to lower ovarian reserve, indexed by AMH. In addition, there was a positive association between neighborhood poverty and AMH in younger women that attenuated in the older women. Together, results suggest that neighborhood disadvantage may have detrimental impacts that manifest as initially higher AMH, resulting in greater ovarian follicle loss over time. However, it remains unclear whether these results examining differences across women may replicate when AMH declines by neighborhood poverty are examined longitudinally.

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来源期刊
CiteScore
5.40
自引率
7.40%
发文量
330
审稿时长
3-8 weeks
期刊介绍: ​Menopause, published monthly, provides a forum for new research, applied basic science, and clinical guidelines on all aspects of menopause. The scope and usefulness of the journal extend beyond gynecology, encompassing many varied biomedical areas, including internal medicine, family practice, medical subspecialties such as cardiology and geriatrics, epidemiology, pathology, sociology, psychology, anthropology, and pharmacology. This forum is essential to help integrate these areas, highlight needs for future research, and enhance health care.
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