功能连接的性别差异和基于连接体的阿尔茨海默病预测模型的预测作用。

IF 2.9 3区 医学 Q2 NEUROSCIENCES
Yuqing Li, Wanqiu Zhu, Shanshan Zhou, Hui Li, Ziwen Gao, Ziang Huang, Xiaohu Li, Yongqiang Yu, Xiaoshu Li
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引用次数: 0

摘要

阿尔茨海默病(AD)是一种以认知能力下降为特征的神经退行性疾病。阿尔茨海默病的进展存在性别差异,但其神经机制尚不十分清楚。本研究的目的是利用基于连接组的预测建模(CPM),探讨在AD不同阶段大脑功能连接(FC)的性别差异及其对蒙特利尔认知评估(MoCA)评分的预测能力。研究人员收集了 81 名注意力缺失症患者(44 名女性)、78 名失忆性轻度认知障碍患者(44 名女性)和 92 名健康对照者(50 名女性)的静息态功能磁共振成像。进行了 FC 分析,并使用双因素方差分析研究了性别和组别之间的交互效应。CPM用于预测MoCA得分。左侧额叶背外侧上回和左侧颞中回、左侧楔前回和右侧钙裂周围皮层、左侧楔前回和左侧枕中回、左侧颞中回和左侧中央前回以及左侧颞中回和右侧楔前回之间的FC存在性别与组别的交互效应。在 CPM 中,阳性网络预测模型能显著预测男性和女性的 MoCA 分数。左侧楔前回和左侧枕中回之间以及左侧颞中回和右侧楔骨之间的FC对女性患者的MoCA评分有明显的性别组交互效应。我们的研究结果表明,在AD的不同阶段,FC存在性别差异。性别特异性FC可进一步预测个体的MoCA评分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Sex differences in functional connectivity and the predictive role of the connectome-based predictive model in Alzheimer's disease

Sex differences in functional connectivity and the predictive role of the connectome-based predictive model in Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline. Sex differences in the progression of AD exist, but the neural mechanisms are not well understood. The purpose of the current study was to explore sex differences in brain functional connectivity (FC) at different stages of AD and their predictive ability on Montreal Cognitive Assessment (MoCA) scores using connectome-based predictive modeling (CPM). Resting-state functional magnetic resonance imaging was collected from 81 AD patients (44 females), 78 amnestic mild cognitive impairment patients (44 females), and 92 healthy controls (50 females). The FC analysis was conducted and the interaction effect between sex and group was investigated using two-factor variance analysis. The CPM was used to predict MoCA scores. There were sex-by-group interaction effects on FC between the left dorsolateral superior frontal gyrus and left middle temporal gyrus, left precuneus and right calcarine fissure surrounding cortex, left precuneus and left middle occipital gyrus, left middle temporal gyrus and left precentral gyrus, and between the left middle temporal gyrus and right cuneus. In the CPM, the positive network predictive model significantly predicted MoCA scores in both males and females. There were significant sex-by-group interaction effects on FC between the left precuneus and left middle occipital gyrus, and between the left middle temporal gyrus and right cuneus could predict MoCA scores in female patients. Our results suggest that there are sex differences in FC at different stages of AD. The sex-specific FC can further predict MoCA scores at individual level.

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来源期刊
Journal of Neuroscience Research
Journal of Neuroscience Research 医学-神经科学
CiteScore
9.50
自引率
2.40%
发文量
145
审稿时长
1 months
期刊介绍: The Journal of Neuroscience Research (JNR) publishes novel research results that will advance our understanding of the development, function and pathophysiology of the nervous system, using molecular, cellular, systems, and translational approaches. JNR covers both basic research and clinical aspects of neurology, neuropathology, psychiatry or psychology. The journal focuses on uncovering the intricacies of brain structure and function. Research published in JNR covers all species from invertebrates to humans, and the reports inform the readers about the function and organization of the nervous system, with emphasis on how disease modifies the function and organization.
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