巨噬细胞:抗药性的隐形罪犯

IF 4.7 3区 医学 Q2 IMMUNOLOGY
Journal of Innate Immunity Pub Date : 2024-01-01 Epub Date: 2024-03-05 DOI:10.1159/000538212
Yimin Ding, Qian Cao, Wenjuan Yang, Junjie Xu, Peng Xiao
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引用次数: 0

摘要

背景 虽然研究人员在开发药物方面做出了巨大努力,但一个令人失望的现实是,耐药性的出现是大多数患者无法避免的现实。近年来,新出现的证据表明,耐药性与免疫失调之间存在联系。摘要 作为一种分布广泛、功能多样的先天性免疫细胞,巨噬细胞在维持组织稳态方面发挥着至关重要的作用。然而,人们逐渐意识到,巨噬细胞会破坏各种类型疾病的治疗药物的作用。重编程巨噬细胞功能已被证明能有效恢复患者对治疗的反应性。在此,我们全面回顾了巨噬细胞如何对药物做出反应,以及巨噬细胞在癌症、炎症性疾病和代谢性疾病中导致治疗无效的机制。此外,我们还讨论了基于巨噬细胞的联合疗法的未来前景。重要信息 以巨噬细胞为靶点是克服免疫疾病耐药性的一种前景广阔的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Macrophage: Hidden Criminal in Therapy Resistance.

Background: Although substantial efforts have been made by researchers to develop drugs, a disappointing reality is that the emergence of drug resistance is an unavoidable reality for the majority of patients. In recent years, emerging evidence suggests a connection between drug resistance and immune dysregulation.

Summary: As a ubiquitously distributed, versatile innate immune cell, macrophages play essential roles in maintaining tissue homeostasis in a steady state. Nevertheless, it is becoming aware that macrophages undermine the action of therapeutic drugs across various disease types. Reprogramming macrophage function has been proven to be effective in restoring patient responsiveness to treatment. Herein, we comprehensively reviewed how macrophages respond to drugs and the mechanisms by which they contribute to treatment unresponsiveness in cancer, inflammatory diseases, and metabolic diseases. In addition, future prospects in macrophage-based combination therapy were discussed.

Key messages: Targeting macrophages is a promising strategy for overcoming drug resistance in immune disorders.

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来源期刊
Journal of Innate Immunity
Journal of Innate Immunity 医学-免疫学
CiteScore
10.50
自引率
1.90%
发文量
35
审稿时长
7.5 months
期刊介绍: The ''Journal of Innate Immunity'' is a bimonthly journal covering all aspects within the area of innate immunity, including evolution of the immune system, molecular biology of cells involved in innate immunity, pattern recognition and signals of ‘danger’, microbial corruption, host response and inflammation, mucosal immunity, complement and coagulation, sepsis and septic shock, molecular genomics, and development of immunotherapies. The journal publishes original research articles, short communications, reviews, commentaries and letters to the editors. In addition to regular papers, some issues feature a special section with a thematic focus.
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